AIM: Local antiseptics are used for desinfection of skin and for lavage of wounds. The aim of this study was to determine the tissue toxicity of different antiseptics and to measure the irritation score (IS) and the irritation threshold (IT) for each substance. METHOD: The tissue compatibilities of Dibromol, Kodan, Jodobac, Octenisept, Lavasept 0.2 %, hydrogen peroxide, chlorhexidindigluconate 0.5 % and 2-propanol 60 % were evaluated in the in vivo hens eggs chorion-allantoic membrane test (HET-CAM). RESULTS: We found the most severe tissue toxicity for chlorhexidin digluconate 0.5 % (IS 20) and Kodan (IS 18). Irritating values were found for Dibromol (IS 14), Octenisept (IS 14) and 2-propanol 60 % (IS 13). Moderate vascular injuries were caused by Jodobac (IS 2). In the HET-CAM test Lavasept 0.2 % (IS 0) and hydrogen peroxide (IS 0) showed no tissue toxicity. CONCLUSION: Our results show that some of the tested antiseptics might cause severe vascular injuries as a sign of tissue toxicity. The tissue compatibility of Lavasept 0.2 % and hydrogen peroxide is much better than the compatibility of the other tested substances. With focus on the literature and our results, Lavasept 0.2 % can be recommended as the local antiseptic of choice.
AIM: Local antiseptics are used for desinfection of skin and for lavage of wounds. The aim of this study was to determine the tissue toxicity of different antiseptics and to measure the irritation score (IS) and the irritation threshold (IT) for each substance. METHOD: The tissue compatibilities of Dibromol, Kodan, Jodobac, Octenisept, Lavasept 0.2 %, hydrogen peroxide, chlorhexidindigluconate 0.5 % and 2-propanol 60 % were evaluated in the in vivo hens eggs chorion-allantoic membrane test (HET-CAM). RESULTS: We found the most severe tissue toxicity for chlorhexidin digluconate 0.5 % (IS 20) and Kodan (IS 18). Irritating values were found for Dibromol (IS 14), Octenisept (IS 14) and 2-propanol 60 % (IS 13). Moderate vascular injuries were caused by Jodobac (IS 2). In the HET-CAM test Lavasept 0.2 % (IS 0) and hydrogen peroxide (IS 0) showed no tissue toxicity. CONCLUSION: Our results show that some of the tested antiseptics might cause severe vascular injuries as a sign of tissue toxicity. The tissue compatibility of Lavasept 0.2 % and hydrogen peroxide is much better than the compatibility of the other tested substances. With focus on the literature and our results, Lavasept 0.2 % can be recommended as the local antiseptic of choice.
Authors: Eric Röhner; Paula Kolar; Joern B Seeger; Joerg Arnholdt; Kathi Thiele; Carsten Perka; Georg Matziolis Journal: Int Orthop Date: 2011-01-16 Impact factor: 3.075
Authors: T Hirsch; F Jacobsen; A Rittig; O Goertz; A Niederbichler; H U Steinau; H M Seipp; L Steinstraesser Journal: Hautarzt Date: 2009-12 Impact factor: 0.751
Authors: Eric Röhner; Paula Hoff; Tobias Winkler; Philipp von Roth; Jörn Bengt Seeger; Carsten Perka; Georg Matziolis Journal: J Histotechnol Date: 2011-03 Impact factor: 0.714
Authors: C Marquardt; E Matuschek; E Bölke; P A Gerber; M Peiper; J V Seydlitz-Kurzbach; B A Buhren; M van Griensven; W Budach; M Hassan; G Kukova; R Mota; D Höfer; K Orth; W Fleischmann Journal: Eur J Med Res Date: 2010-05-18 Impact factor: 2.175