Literature DB >> 12688530

Kinetics of inhibition of ribonuclease P activity by peptidyltransferase inhibitors. Effect of antibiotics on RNase P.

Dimitra Kalavrizioti1, Anastassios Vourekas, Apostolos Tekos, Antigoni Tsagla, Constantinos Stathopoulos, Denis Drainas.   

Abstract

A cell-free system derived from Dictyostelium discoideum has been used to study the kinetics of inhibition of RNase P by puromycin, amicetin and blasticidin S. Detailed kinetic analysis showed that the type of inhibition of RNase P activity by puromycin is simple competitive, whereas the type of inhibition by amicetin and blasticidin S is simple non-competitive. On the basis of Ki values amicetin is stronger inhibitor than puromycin and blasticidin S.

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Year:  2003        PMID： 12688530     DOI： 10.1023/a:1022290110116

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  30 in total

1.  Synthetic inhibitors of the processing of pretransfer RNA by the ribonuclease P ribozyme: enzyme inhibitors which act by binding to substrate.

Authors:  Y Hori; E V Bichenkova; A N Wilton; M N El-Attug; S Sadat-Ebrahimi; T Tanaka; Y Kikuchi; M Araki; Y Sugiura; K T Douglas
Journal:  Biochemistry       Date:  2001-01-23       Impact factor: 3.162

2.  Effect of peptidyltransferase inhibitors on ribonuclease P activity from Dictyostelium discoideum. Effect of antibiotics on RNase P.

Authors:  C Stathopoulos; A Tsagla; A Tekos; D Drainas
Journal:  Mol Biol Rep       Date:  2000-06       Impact factor: 2.316

3.  Characterization of two scleroderma autoimmune antigens that copurify with human ribonuclease P.

Authors:  P S Eder; R Kekuda; V Stolc; S Altman
Journal:  Proc Natl Acad Sci U S A       Date:  1997-02-18       Impact factor: 11.205

Review 4.  The binding of antibiotics to RNA.

Authors:  M G Wallis; R Schroeder
Journal:  Prog Biophys Mol Biol       Date:  1997       Impact factor: 3.667

5.  Identification of the universally conserved core of ribonuclease P RNA.

Authors:  J L Chen; N R Pace
Journal:  RNA       Date:  1997-06       Impact factor: 4.942

6.  Inhibition of bacterial RNase P by aminoglycoside-arginine conjugates.

Authors:  Timothy D Eubank; Roopa Biswas; Milan Jovanovic; Alexander Litovchick; Aviva Lapidot; Venkat Gopalan
Journal:  FEBS Lett       Date:  2002-01-30       Impact factor: 4.124

7.  Protein synthesis inhibitors and catalytic RNA. Effect of puromycin on tRNA precursor processing by the RNA component of Escherichia coli RNase P.

Authors:  A Vioque
Journal:  FEBS Lett       Date:  1989-03-27       Impact factor: 4.124

8.  The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme.

Authors:  C Guerrier-Takada; K Gardiner; T Marsh; N Pace; S Altman
Journal:  Cell       Date:  1983-12       Impact factor: 41.582

9.  Ribonuclease P of Tetrahymena thermophila.

Authors:  H L True; D W Celander
Journal:  J Biol Chem       Date:  1996-07-12       Impact factor: 5.157

10.  Aminoacylaminonucleoside inhibitors of protein synthesis. A new approach for evaluating their potency.

Authors:  D A Theocharis; D L Kalpaxis; C Coutsogeorgopoulos
Journal:  Eur J Biochem       Date:  1986-09-15
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  1 in total

Review 1.  tRNAs as antibiotic targets.

Authors:  Shaileja Chopra; John Reader
Journal:  Int J Mol Sci       Date:  2014-12-25       Impact factor: 5.923
  1 in total

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