Literature DB >> 11092557

Effect of peptidyltransferase inhibitors on ribonuclease P activity from Dictyostelium discoideum. Effect of antibiotics on RNase P.

C Stathopoulos1, A Tsagla, A Tekos, D Drainas.   

Abstract

The effect of several peptidyltransferase inhibitors on ribonuclease P activity from Dictyostelium discoideum was investigated. Among the inhibitors tested puromycin, amicetin and blasticidin S revealed a dose-dependent inhibition of tRNA maturation. Blasticidin S and amicetin do not compete with puromycin for the same site on the enzyme, suggesting the existence of distinct antibiotic binding sites on D. discoideum RNase P. Inhibition experiments further indicate that binding sites for blasticidin S and amicetin overlap.

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Year:  2000        PMID： 11092557     DOI： 10.1023/a:1007183306082

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  27 in total

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Authors:  J A Pannucci; E S Haas; T A Hall; J K Harris; J W Brown
Journal:  Proc Natl Acad Sci U S A       Date:  1999-07-06       Impact factor: 11.205

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Review 3.  The binding of antibiotics to RNA.

Authors:  M G Wallis; R Schroeder
Journal:  Prog Biophys Mol Biol       Date:  1997       Impact factor: 3.667

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Authors:  J L Chen; N R Pace
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Journal:  FEBS Lett       Date:  1989-03-27       Impact factor: 4.124

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Journal:  Adv Enzymol Relat Areas Mol Biol       Date:  1988

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Authors:  C Guerrier-Takada; K Gardiner; T Marsh; N Pace; S Altman
Journal:  Cell       Date:  1983-12       Impact factor: 41.582

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Authors:  H L True; D W Celander
Journal:  J Biol Chem       Date:  1996-07-12       Impact factor: 5.157

9.  Small molecules that selectively block RNA binding of HIV-1 Rev protein inhibit Rev function and viral production.

Authors:  M L Zapp; S Stern; M R Green
Journal:  Cell       Date:  1993-09-24       Impact factor: 41.582

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Journal:  RNA       Date:  1995-03       Impact factor: 4.942
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  2 in total

1.  Kinetics of inhibition of ribonuclease P activity by peptidyltransferase inhibitors. Effect of antibiotics on RNase P.

Authors:  Dimitra Kalavrizioti; Anastassios Vourekas; Apostolos Tekos; Antigoni Tsagla; Constantinos Stathopoulos; Denis Drainas
Journal:  Mol Biol Rep       Date:  2003-03       Impact factor: 2.316

Review 2.  Revisiting Drug Development Against the Neglected Tropical Disease, Amebiasis.

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Journal:  Front Cell Infect Microbiol       Date:  2021-02-24       Impact factor: 5.293
  2 in total

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