Literature DB >> 12684778

Molecular cloning and expression analysis of the mouse Spot-2 gene in pituitary development.

Toshinobu Miyamoto1, Shiga Hasuike, Kazuo Sengoku, Naoyuki Takuma, Hiroaki Hayashi, Yoshihito Sasaki, Tsuyoshi Yamashita, Mutsuo Ishikawa.   

Abstract

Mouse Spot-1 is a DNA-binding protein with a domain (His-Thr) encoded by p(CA)n repeats. Spot-1 interacts with the nuclear localization signal (NLS) I of p53 through its His-Thr domain. In this study we describe the cloning and expression patterns of a novel gene encoding a protein containing a His-Thr domain, Spot-2. Spot-2 is exclusively expressed in the pituitary from stage E13.5 to E15.5. Mouse Lhx3 plays a critical role during early organogenesis in the pituitary. The Spot-2 gene appears to be a downstream gene of Lhx3. It is suggested that Spot-2 plays important roles in pituitary development.

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Year:  2003        PMID： 12684778     DOI： 10.1007/s00427-003-0313-0

Source DB:  PubMed          Journal:  Dev Genes Evol        ISSN： 0949-944X            Impact factor:   0.900


  10 in total

1.  Sensitivity and specificity of nucleic acid probes for potato leafroll luteovirus detection.

Authors:  D J Robinson; J Romero
Journal:  J Virol Methods       Date:  1991 Sep-Oct       Impact factor: 2.014

Review 2.  The hypothalamic-pituitary axis: co-development of two organs.

Authors:  M Treier; M G Rosenfeld
Journal:  Curr Opin Cell Biol       Date:  1996-12       Impact factor: 8.382

3.  Specification of pituitary cell lineages by the LIM homeobox gene Lhx3.

Authors:  H Z Sheng; A B Zhadanov; B Mosinger; T Fujii; S Bertuzzi; A Grinberg; E J Lee; S P Huang; K A Mahon; H Westphal
Journal:  Science       Date:  1996-05-17       Impact factor: 47.728

4.  Multistep control of pituitary organogenesis.

Authors:  H Z Sheng; K Moriyama; T Yamashita; H Li; S S Potter; K A Mahon; H Westphal
Journal:  Science       Date:  1997-12-05       Impact factor: 47.728

5.  Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism.

Authors:  M W Sornson; W Wu; J S Dasen; S E Flynn; D J Norman; S M O'Connell; I Gukovsky; C Carrière; A K Ryan; A P Miller; L Zuo; A S Gleiberman; B Andersen; W G Beamer; M G Rosenfeld
Journal:  Nature       Date:  1996-11-28       Impact factor: 49.962

6.  The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary.

Authors:  S Kimura; Y Hara; T Pineau; P Fernandez-Salguero; C H Fox; J M Ward; F J Gonzalez
Journal:  Genes Dev       Date:  1996-01-01       Impact factor: 11.361

7.  Deregulation of cyclin E in breast cancer.

Authors:  K Keyomarsi; D Conte; W Toyofuku; M P Fox
Journal:  Oncogene       Date:  1995-09-07       Impact factor: 9.867

8.  Gsh-1, an orphan Hox gene, is required for normal pituitary development.

Authors:  H Li; P S Zeitler; M T Valerius; K Small; S S Potter
Journal:  EMBO J       Date:  1996-02-15       Impact factor: 11.598

9.  Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1.

Authors:  S Li; E B Crenshaw; E J Rawson; D M Simmons; L W Swanson; M G Rosenfeld
Journal:  Nature       Date:  1990-10-11       Impact factor: 49.962

Review 10.  How many homeobox genes does it take to make a pituitary gland?

Authors:  D E Watkins-Chow; S A Camper
Journal:  Trends Genet       Date:  1998-07       Impact factor: 11.639
  10 in total

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