| Literature DB >> 8934515 |
M W Sornson1, W Wu, J S Dasen, S E Flynn, D J Norman, S M O'Connell, I Gukovsky, C Carrière, A K Ryan, A P Miller, L Zuo, A S Gleiberman, B Andersen, W G Beamer, M G Rosenfeld.
Abstract
The gene apparently responsible for a heritable form of murine pituitary-dependent dwarfism (Ames dwarf, df) has been positionally cloned, identifying a novel, tissue-specific, paired-like homeodomain transcription factor, termed Prophet of Pit-1 (Prop-1). The df phenotype results from an apparent failure of initial determination of the Pit-1 lineage required for production of growth hormone, prolactin or thyroid-stimulating hormone, resulting in dysmorphogenesis and failure to activate Pit-1 gene expression. These results imply that a cascade of tissue-specific regulators is responsible for the determination and differentiation of specific cell lineages in pituitary organogenesis.Entities:
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Year: 1996 PMID： 8934515 DOI： 10.1038/384327a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962