| Literature DB >> 12673566 |
Hiroko Kuwabara1, Motomu Tsuji, Yasuyoshi Yoshii, Yoshiteru Kakuno, Toshikazu Akioka, Takuya Kotani, Noriaki Iwao, Toshiaki Hanafusa, Tsunehiko Ikeda, Hiroshi Mori.
Abstract
A case of a nasal-type NK/T cell lymphoma of the orbit with distant metastases is reported. The orbital lymphoma was angiodestructive with prominent necrosis and frequent apoptosis. Lymphoma cells were positive for CD56, cytotoxic molecules (granzyme B and TIA-1), and EBV. Despite local radiotherapy, the patient had a highly aggressive clinical course. A postmortem examination revealed distant metastases to the heart and lungs exhibiting angiocentric growth. TCR and Ig genes of a cardiac lesion were in germ line configuration. This case demonstrated that nasal-type NK/T cell lymphomas with a poor prognosis can occur in the orbit. Copyright 2003, Elsevier Inc.Entities:
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Year: 2003 PMID： 12673566 DOI： 10.1053/hupa.2003.33
Source DB: PubMed Journal: Hum Pathol ISSN： 0046-8177 Impact factor: 3.466