Literature DB >> 12673027

Inhibition of NO production by highly-oxygenated diterpenes of Orthosiphon stamineus and their structure-activity relationship.

Suresh Awale1, Yasuhiro Tezuka, Arjun H Banskota, Shigetoshi Kadota.   

Abstract

Nitric oxide (NO) has been implemented in various pathological processes. In the present study, 47 highly-oxygenated isopimarane-type and novel carbon framework staminane-type diterpenes isolated from Orthosiphon stamineus of Indonesia, Okinawa, Myanmar and Vietnam were evaluated for their inhibitory activity in NO production by lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells. All the isolated diterpenes showed concentration-dependent inhibition of NO production in LPS-activated macrophage-like J774.1 cells, and based on the results, their structure-activity relationship were established.

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Year:  2003        PMID： 12673027     DOI： 10.1248/bpb.26.468

Source DB:  PubMed          Journal:  Biol Pharm Bull        ISSN： 0918-6158            Impact factor:   2.233


  6 in total

1.  Bioactive Compounds from Medicinal Plants in Myanmar.

Authors:  Nwet Nwet Win; Hiroyuki Morita
Journal:  Prog Chem Org Nat Prod       Date:  2021

2.  Antiapoptotic and Antioxidant Properties of Orthosiphon stamineus Benth (Cat's Whiskers): Intervention in the Bcl-2-Mediated Apoptotic Pathway.

Authors:  Siddig Ibrahim Abdelwahab; Syam Mohan; Manal Mohamed Elhassan; Nabil Al-Mekhlafi; Abdelbasit Adam Mariod; Ahmad Bustamam Abdul; Mahmood Ameen Abdulla; Khalid M Alkharfy
Journal:  Evid Based Complement Alternat Med       Date:  2010-12-30       Impact factor: 2.629

3.  Orthosiphon stamineus Standardized Extract Reverses Streptozotocin-induced Alzheimer's Disease-Like Condition in a Rat Model.

Authors:  Thaarvena Retinasamy; Mohd Farooq Shaikh; Yatinesh Kumari; Syafiq Asnawi Zainal Abidin; Iekhsan Othman
Journal:  Biomedicines       Date:  2020-04-30

4.  Clerodendranoic acid, a new phenolic acid from Clerodendranthus spicatus.

Authors:  Qingxia Zheng; Zhaocui Sun; Xiaopo Zhang; Jinquan Yuan; Haifeng Wu; Junshan Yang; Xudong Xu
Journal:  Molecules       Date:  2012-11-19       Impact factor: 4.411

Review 5.  Orthosiphon stamineus Benth. is an Outstanding Food Medicine: Review of Phytochemical and Pharmacological Activities.

Authors:  Kamran Ashraf; Sadia Sultan; Aishah Adam
Journal:  J Pharm Bioallied Sci       Date:  2018 Jul-Sep

6.  In vitro antioxidant, antimicrobial and antiproliferative studies of four different extracts of Orthosiphon stamineus, Gynura procumbens and Ficus deltoidea.

Authors:  Kamran Ashraf; Hasseri Halim; Siong Meng Lim; Kalavathy Ramasamy; Sadia Sultan
Journal:  Saudi J Biol Sci       Date:  2019-11-18       Impact factor: 4.219
  6 in total

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