Literature DB >> 12672579

Modulatory effect of fosfomycin on acute inflammation in the rat air pouch model.

K Morikawa1, M Nonaka, Ikuko Torii, S Morikawa.   

Abstract

We examined the effect of fosfomycin (FOM) on the inflammatory response induced by carrageenan in the rat. Air pouches were induced subcutaneously on the backs of rats and injected with carrageenan. The rats were treated with either vehicle or FOM at a dose of 100 mg/kg 1 h before carrageenan challenge. After carrageenan challenge (48 h), the air pouches were removed and analyzed. The volume, protein amounts and cell counts in the exudate obtained from FOM-treated animals were significantly reduced compared with that from vehicle-treated animals. The contents of PGE(2) and TNF-alpha, and mRNA for cyclooxygenase-2 were also markedly suppressed in FOM-treated rats. Histological examination showed suppression of the inflammatory response in the pouch tissues from FOM-treated rats.

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Year:  2003        PMID： 12672579     DOI： 10.1016/s0924-8579(02)00358-8

Source DB:  PubMed          Journal:  Int J Antimicrob Agents        ISSN： 0924-8579            Impact factor:   5.283


  8 in total

1.  Efficacy of fosfomycin in experimental osteomyelitis due to methicillin-resistant Staphylococcus aureus.

Authors:  W Poeppl; S Tobudic; T Lingscheid; R Plasenzotti; N Kozakowski; A Georgopoulos; H Burgmann
Journal:  Antimicrob Agents Chemother       Date:  2010-11-22       Impact factor: 5.191

Review 2.  Pharmacologic advances in the treatment and prevention of respiratory syncytial virus.

Authors:  Kerry M Empey; R Stokes Peebles; Jay K Kolls
Journal:  Clin Infect Dis       Date:  2010-05-01       Impact factor: 9.079

3.  Daptomycin, fosfomycin, or both for treatment of methicillin-resistant Staphylococcus aureus osteomyelitis in an experimental rat model.

Authors:  W Poeppl; S Tobudic; T Lingscheid; R Plasenzotti; N Kozakowski; H Lagler; A Georgopoulos; H Burgmann
Journal:  Antimicrob Agents Chemother       Date:  2011-08-22       Impact factor: 5.191

4.  Immunomodulatory effects of fosfomycin in experimental human endotoxemia.

Authors:  Robert Sauermann; Claudia Marsik; Ilka Steiner; Katja Seir; Tuende Cvitko; Markus Zeitlinger; Oswald Wagner; Christian Joukhadar
Journal:  Antimicrob Agents Chemother       Date:  2007-03-12       Impact factor: 5.191

5.  Fosfomycin suppresses chemokine induction in airway epithelial cells infected with respiratory syncytial virus.

Authors:  Tamaki Okabayashi; Shin-ichi Yokota; Yuko Yoto; Hiroyuki Tsutsumi; Nobuhiro Fujii
Journal:  Clin Vaccine Immunol       Date:  2009-04-15

6.  Activities of fosfomycin and rifampin on planktonic and adherent Enterococcus faecalis strains in an experimental foreign-body infection model.

Authors:  Alessandra Oliva; Ulrika Furustrand Tafin; Elena Maryka Maiolo; Safaa Jeddari; Bertrand Bétrisey; Andrej Trampuz
Journal:  Antimicrob Agents Chemother       Date:  2013-10-21       Impact factor: 5.191

7.  Fosfomycin suppresses RS-virus-induced Streptococcus pneumoniae and Haemophilus influenzae adhesion to respiratory epithelial cells via the platelet-activating factor receptor.

Authors:  Shin-ichi Yokota; Tamaki Okabayashi; Yuko Yoto; Tsukasa Hori; Hiroyuki Tsutsumi; Nobuhiro Fujii
Journal:  FEMS Microbiol Lett       Date:  2010-06-28       Impact factor: 2.742

8.  Increase in the Antioxidant and Anti-Inflammatory Activity of Euterpe oleracea Martius Oil Complexed in β-Cyclodextrin and Hydroxypropyl-β-Cyclodextrin.

Authors:  Thalita Sévia Soares de Almeida Magalhães; Pollyana Cristina de Oliveira Macedo; Érika Cibely Pinheiro da Costa; Emanuella de Aragão Tavares; Valéria Costa da Silva; Gerlane Coelho Bernardo Guerra; Joquebede Rodrigues Pereira; Telma Maria de Araújo Moura Lemos; Marília Medeiros Fernandes de Negreiros; Hugo Alexandre de Oliveira Rocha; Attilio Converti; Ádley Antonini Neves de Lima
Journal:  Int J Mol Sci       Date:  2021-10-26       Impact factor: 5.923
  8 in total

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