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Literature DB >> 12671669

Improving the evaluation of new cancer treatments: challenges and opportunities.

Mace L Rothenberg¹, David P Carbone, David H Johnson.

Abstract

There are, at present, ten times more anticancer drugs being tested in clinical trials than there were 15 years ago. Many of the new classes of agents, however, are predicted to work in only small subpopulations of patients, target unconventional aspects of tumour development and interact with other agents in an unpredictable manner. How can clinical trials be re-designed to accommodate the new features of targeted anticancer drugs?

Entities: Disease Species

Mesh：

Substances：
Antineoplastic Agents

Year: 2003 PMID： 12671669 DOI： 10.1038/nrc1047

Source DB: PubMed Journal: Nat Rev Cancer ISSN： 1474-175X Impact factor: 60.716

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Cited

21 in total

1. Molecular Imaging of Proteases in Cancer.

Authors: Yunan Yang; Hao Hong; Yin Zhang; Weibo Cai
Journal: Cancer Growth Metastasis Date: 2009-08-17

Review 2. Challenges in clinical studies with multiple imaging probes.

Authors: Kenneth A Krohn; Finbarr O'Sullivan; John Crowley; Janet F Eary; Hannah M Linden; Jeanne M Link; David A Mankoff; Mark Muzi; Joseph G Rajendran; Alexander M Spence; Kristin R Swanson
Journal: Nucl Med Biol Date: 2007-10 Impact factor: 2.408

3. Adenoviral vectors expressing human endostatin-angiostatin and soluble Tie2: enhanced suppression of tumor growth and antiangiogenic effects in a prostate tumor model.

Authors: Sudhanshu P Raikwar; Constance J Temm; Nandita S Raikwar; Chinghai Kao; Bruce A Molitoris; Thomas A Gardner
Journal: Mol Ther Date: 2005-10-05 Impact factor: 11.454

Improving the evaluation of new cancer treatments: challenges and opportunities.

1. Molecular Imaging of Proteases in Cancer.

Review 2. Challenges in clinical studies with multiple imaging probes.

3. Adenoviral vectors expressing human endostatin-angiostatin and soluble Tie2: enhanced suppression of tumor growth and antiangiogenic effects in a prostate tumor model.

Review 4. New target-based agents involve new clinical trial designs.

Review 5. Hepatic tumor growth: target for angiogenesis inhibition?

Review 6. DNA array-based gene profiling: from surgical specimen to the molecular portrait of cancer.

Review 7. Drug development in oncology: classical cytotoxics and molecularly targeted agents.

8. A large animal model to evaluate the effects of Hsp90 inhibitors for the treatment of lung adenocarcinoma.

9. Developing and validating continuous genomic signatures in randomized clinical trials for predictive medicine.

Review 10. Metastasis: recent discoveries and novel treatment strategies.