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Literature DB >> 12671652

New insights into the roles of agrin.

Abstract

The heparan sulphate proteoglycan agrin is expressed as several isoforms in various tissues. Agrin is best known as a crucial organizer of postsynaptic differentiation at the neuromuscular junction, but it has recently also been implicated in the formation of the immunological synapse, the organization of the cytoskeleton and the amelioration of function in diseased muscle. So the activities of agrin might be of broader significance than previously anticipated.

Entities: Gene

Mesh：

Substances：
Agrin
Protein Isoforms

Year: 2003 PMID： 12671652 DOI： 10.1038/nrm1074

Source DB: PubMed Journal: Nat Rev Mol Cell Biol ISSN： 1471-0072 Impact factor: 94.444

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Cited

116 in total

1. Inhibition of synapse assembly in mammalian muscle in vivo by RNA interference.

Authors: Xian Chu Kong; Patrizia Barzaghi; Markus A Ruegg
Journal: EMBO Rep Date: 2004-01-16 Impact factor: 8.807

2. Cytokines activate genes of the endocytotic pathway in insulin-producing RINm5F cells.

Authors: K L A Souza; M Elsner; P C F Mathias; S Lenzen; M Tiedge
Journal: Diabetologia Date: 2004-07-10 Impact factor: 10.122

3. The nicotinic acetylcholine receptor and the Na,K-ATPase alpha2 isoform interact to regulate membrane electrogenesis in skeletal muscle.

Authors: Judith A Heiny; Violetta V Kravtsova; Frederic Mandel; Tatiana L Radzyukevich; Boubacar Benziane; Alexander V Prokofiev; Steen E Pedersen; Alexander V Chibalin; Igor I Krivoi
Journal: J Biol Chem Date: 2010-07-01 Impact factor: 5.157

Review 4. Casting a net on dendritic spines: the extracellular matrix and its receptors.

Authors: Lorraine E Dansie; Iryna M Ethell
Journal: Dev Neurobiol Date: 2011-11 Impact factor: 3.964

Review 5. Amyloid accomplices and enforcers.

Authors: Andrei T Alexandrescu
Journal: Protein Sci Date: 2004-12-02 Impact factor: 6.725

New insights into the roles of agrin.

1. Inhibition of synapse assembly in mammalian muscle in vivo by RNA interference.

2. Cytokines activate genes of the endocytotic pathway in insulin-producing RINm5F cells.

3. The nicotinic acetylcholine receptor and the Na,K-ATPase alpha2 isoform interact to regulate membrane electrogenesis in skeletal muscle.

Review 4. Casting a net on dendritic spines: the extracellular matrix and its receptors.

Review 5. Amyloid accomplices and enforcers.

6. Organization of synaptic myonuclei by Syne proteins and their role during the formation of the nerve-muscle synapse.

Review 7. Extracellular matrix of the central nervous system: from neglect to challenge.

8. A novel role for embigin to promote sprouting of motor nerve terminals at the neuromuscular junction.

9. Non-synaptic roles of acetylcholinesterase and agrin.

10. NMR solution structure of the neurotrypsin Kringle domain.