| Literature DB >> 12668017 |
William H Miller1, Peter J Manley, Russell D Cousins, Karl F Erhard, Dirk A Heerding, Chet Kwon, Stephen T Ross, James M Samanen, Dennis T Takata, Irene N Uzinskas, Catherine C K Yuan, R Curtis Haltiwanger, Catherine J Gress, Michael W Lark, Shing Mei Hwang, Ian E James, David J Rieman, Robert N Willette, Tian Li Yue, Leonard M Azzarano, Kevin L Salyers, Brian R Smith, Keith W Ward, Kyung O Johanson, William F Huffman.
Abstract
In our continuing efforts to identify small molecule vitronectin receptor antagonists, we have discovered a series of phenylbutyrate derivatives, exemplified by 16, which have good potency and excellent oral bioavailability (approximately 100% in rats). This new series is derived conceptually from opening of the seven-membered ring of SB-265123.Entities:
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Year: 2003 PMID： 12668017 DOI： 10.1016/s0960-894x(03)00102-1
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823