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Literature DB >> 27571167

Palladium-Catalyzed Enantioselective Redox-Relay Heck Arylation of 1,1-Disubstituted Homoallylic Alcohols.

Zhi-Min Chen¹, Margaret J Hilton¹, Matthew S Sigman¹.

Abstract

An enantioselective redox-relay oxidative Heck arylation of 1,1-disubstituted alkenes to construct β-stereocenters was developed using a new pyridyl-oxazoline ligand. Various 1,2-diaryl carbonyl compounds were readily obtained in moderate yield and good to excellent enantioselectivity. Additionally, analysis of the reaction outcomes using multidimensional correlations revealed that enantioselectivity is tied to specific electronic features of the 1,1-disubstituted alkenol and the extent of polarizability of the ligand.

Entities: Chemical Disease Gene

Mesh：

Substances：
Alcohols
Alkenes
Palladium

Year: 2016 PMID： 27571167 PMCID： PMC5039009 DOI： 10.1021/jacs.6b06994

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

44 in total

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