BACKGROUND: The hippocampus, thalamus and basal ganglia are among the brain regions of major interest in schizophrenia. AIMS: The purpose of this study was to corroborate previous findings of reduced N-acetylaspartate in the hippocampal and thalamic regions and to investigate possible metabolite changes in the putamen in schizophrenia. METHOD: MRSI study of the thalamus, basal ganglia, and hippocampus in 13 schizophrenic patients under stable medication and age-matched healthy controls. RESULTS: A decrease of the N-acetylaspartate signal was found in the hippocampal region and the thalamus but not in the putamen of patients compared to controls. No significant group differences in the signals from creatine and phosphocreatine, and choline-containing compounds were found in the hippocampal region and the putamen but the signal from choline-containing compounds was decreased in the thalamus of patients. CONCLUSION: Metabolic processes in the basal ganglia of schizophrenic patients seem to be opposite the hippocampal and thalamus findings.
BACKGROUND: The hippocampus, thalamus and basal ganglia are among the brain regions of major interest in schizophrenia. AIMS: The purpose of this study was to corroborate previous findings of reduced N-acetylaspartate in the hippocampal and thalamic regions and to investigate possible metabolite changes in the putamen in schizophrenia. METHOD: MRSI study of the thalamus, basal ganglia, and hippocampus in 13 schizophrenicpatients under stable medication and age-matched healthy controls. RESULTS: A decrease of the N-acetylaspartate signal was found in the hippocampal region and the thalamus but not in the putamen of patients compared to controls. No significant group differences in the signals from creatine and phosphocreatine, and choline-containing compounds were found in the hippocampal region and the putamen but the signal from choline-containing compounds was decreased in the thalamus of patients. CONCLUSION: Metabolic processes in the basal ganglia of schizophrenicpatients seem to be opposite the hippocampal and thalamus findings.
Authors: John R Moffett; Brian Ross; Peethambaran Arun; Chikkathur N Madhavarao; Aryan M A Namboodiri Journal: Prog Neurobiol Date: 2007-01-05 Impact factor: 11.685
Authors: Nina Vanessa Kraguljac; Meredith Reid; David White; Rebecca Jones; Jan den Hollander; Deborah Lowman; Adrienne Carol Lahti Journal: Psychiatry Res Date: 2012-09-13 Impact factor: 3.222
Authors: Meredith A Reid; Nina V Kraguljac; Kathy B Avsar; David M White; Jan A den Hollander; Adrienne C Lahti Journal: Schizophr Res Date: 2013-05-21 Impact factor: 4.939
Authors: Patrick Vigren; Anders Tisell; Maria Engström; Thomas Karlsson; Olof Leinhard Dahlqvist; Peter Lundberg; Anne-Marie Landtblom Journal: PLoS One Date: 2013-02-25 Impact factor: 3.240