Literature DB >> 12663099

Lower in vivo brain extracellular GABA concentration in diabetic rats during forced swimming.

Rosane Gomez1, Carmem R Vargas, Moacir Wajner, Helena M T Barros.   

Abstract

Diabetic rats are more immobile during the forced-swimming test (FST) and GABAergic drugs reverse this behavior. We investigated if there is in vivo changes of GABA levels of diabetic rats during the FST. In vivo basal striatal GABA levels of streptozotocin diabetic rats are similar to non-diabetic rats. Non-diabetic rats presented a significant increase in GABA levels after the FST while the increase was delayed and lower in diabetic rats. These results suggest that diabetes may change GABA homeostasis and modify behavioral responses in an animal model of depression.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 12663099     DOI： 10.1016/s0006-8993(03)02340-0

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  8 in total

1.  Insulin reverses anxiety-like behavior evoked by streptozotocin-induced diabetes in mice.

Authors:  Deepali Gupta; Mahesh Radhakrishnan; Yeshwant Kurhe
Journal:  Metab Brain Dis       Date:  2014-04-25       Impact factor: 3.584

2.  Influence of Tacrolimus on Depressive-Like Behavior in Diabetic Rats Through Brain-Derived Neurotrophic Factor Regulation in the Hippocampus.

Authors:  Yoo Jin Shin; Yeon Tae Chun; Sun Woo Lim; Kang Luo; Yi Quan; Sheng Cui; Eun Jeong Ko; Byung Ha Chung; Jiyeong Lee; Seongno Hong; Mun Yong Lee; Hee Gyoo Kang; Chul Woo Yang
Journal:  Neurotox Res       Date:  2019-06-14       Impact factor: 3.911

3.  The forced swim test as a model of depressive-like behavior.

Authors:  Roni Yankelevitch-Yahav; Motty Franko; Avrham Huly; Ravid Doron
Journal:  J Vis Exp       Date:  2015-03-02       Impact factor: 1.355

Review 4.  Function of the GABAergic System in Diabetic Encephalopathy.

Authors:  Hongli Zhou; Zhili Rao; Zuo Zhang; Jiyin Zhou
Journal:  Cell Mol Neurobiol       Date:  2022-04-23       Impact factor: 5.046

5.  Proteomic changes associated with diabetes in the BB-DP rat.

Authors:  D Thor Johnson; Robert A Harris; Stephanie French; Angel Aponte; Robert S Balaban
Journal:  Am J Physiol Endocrinol Metab       Date:  2008-11-04       Impact factor: 4.310

6.  Effects of cyclohexanonic long-chain fatty alcohol, tCFA15 on amino acids in diabetic rat brain: a preliminary study.

Authors:  Chiko Shinbori; Yukihiko Shirayama; Hideaki Mitani; Motoaki Saito; Keisuke Satoh
Journal:  Neurochem Res       Date:  2008-03-13       Impact factor: 3.996

7.  Berberine chloride improved synaptic plasticity in STZ induced diabetic rats.

Authors:  Hamid Kalalian Moghaddam; Tourandokht Baluchnejadmojarad; Mehrdad Roghani; Fatemeh Goshadrou; Abdolaziz Ronaghi
Journal:  Metab Brain Dis       Date:  2013-05-03       Impact factor: 3.584

8.  Time-dependent changes of calbindin D-28K and parvalbumin immunoreactivity in the hippocampus of rats with streptozotocin-induced type 1 diabetes.

Authors:  Sun Shin Yi
Journal:  J Vet Sci       Date:  2013-04-30       Impact factor: 1.672
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.