Literature DB >> 18338258

Effects of cyclohexanonic long-chain fatty alcohol, tCFA15 on amino acids in diabetic rat brain: a preliminary study.

Chiko Shinbori1, Yukihiko Shirayama, Hideaki Mitani, Motoaki Saito, Keisuke Satoh.   

Abstract

The aim of this study was to evaluate the effects of streptozotocin-induced type 1diabetes and a subchronic treatment with cyclohexanonic long-chain fatty alcohol, 3-(15-hydroxypentadecyl)-2,4,4-trimethyl-2-cyclohexen 1-one (tCFA15) on contents of amino acids including aspartate, glutamate, glutamine, GABA, glycine, taurine, alanine, serine, threonine, and arginine in the prefrontal cortex, hippocampus and striatum. Levels of glutamate, threonine, taurine, alanine, arginine, and the ratio of glutamate/glutamine were altered region-differently in the brain of diabetic rats. However, tCFA15 region-specifically antagonized the changes in taurine and arginine levels and the ratio of glutamate/glutamine. The alteration in glutamate/glutamine ratio may indicate that experimental models of type 1 diabetes have abnormalities of neuron-gria interaction in brain.

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Year:  2008        PMID： 18338258     DOI： 10.1007/s11064-008-9611-2

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  59 in total

1.  The effect of streptozotocin-induced diabetes on dopamine2, serotonin1A and serotonin2A receptors in the rat brain.

Authors:  T Sumiyoshi; J Ichikawa; H Y Meltzer
Journal:  Neuropsychopharmacology       Date:  1997-03       Impact factor: 7.853

2.  Peripheral administration of a long-chain fatty alcohol promotes septal cholinergic neurons survival after fimbria-fornix transection.

Authors:  J Borg; P J Kesslak; C W Cotman
Journal:  Brain Res       Date:  1990-06-04       Impact factor: 3.252

3.  Taurine activates GABA(A) but not GABA(B) receptors in rat hippocampal CA1 area.

Authors:  N del Olmo; J Bustamante; R M del Río; J M Solís
Journal:  Brain Res       Date:  2000-05-12       Impact factor: 3.252

4.  Platelet glycine, glutamate and aspartate in primary headache.

Authors:  G D'Andrea; A R Cananzi; R Joseph; M Morra; F Zamberlan; F Ferro Milone; S Grunfeld; K M Welch
Journal:  Cephalalgia       Date:  1991-09       Impact factor: 6.292

5.  N-hexacosanol ameliorates streptozotocin-induced diabetic rat nephropathy.

Authors:  Motoaki Saito; Yukako Kinoshita; Itaru Satoh; Chiko Shinbori; Tomoharu Kono; Takuya Hanada; Jiro Uemasu; Hiroto Suzuki; Masashi Yamada; Keisuke Satoh
Journal:  Eur J Pharmacol       Date:  2006-06-10       Impact factor: 4.432

6.  Association of depression and diabetes complications: a meta-analysis.

Authors:  M de Groot; R Anderson; K E Freedland; R E Clouse; P J Lustman
Journal:  Psychosom Med       Date:  2001 Jul-Aug       Impact factor: 4.312

7.  Diabetes attenuates psychological stress-elicited 5-HT secretion in the prefrontal cortex but not in the amygdala of mice.

Authors:  Shigeo Miyata; Naoko Yamada; Shoko Hirano; Shun-ichi Tanaka; Junzo Kamei
Journal:  Brain Res       Date:  2007-02-04       Impact factor: 3.252

8.  Role of glial metabolism in diabetic encephalopathy as detected by high resolution 13C NMR.

Authors:  María A García-Espinosa; María L García-Martín; Sebastián Cerdán
Journal:  NMR Biomed       Date:  2003 Oct-Nov       Impact factor: 4.044

9.  Water maze learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: effects of insulin treatment.

Authors:  G J Biessels; A Kamal; I J Urban; B M Spruijt; D W Erkelens; W H Gispen
Journal:  Brain Res       Date:  1998-07-27       Impact factor: 3.252

10.  Effects of psychotomimetic and antipsychotic agents on neocortical and striatal concentrations of various amino acids in the rat.

Authors:  Shin-ichiro Sakurai; Sumikazu Ishii; Asami Umino; Dai Shimazu; Naoki Yamamoto; Toru Nishikawa
Journal:  J Neurochem       Date:  2004-09       Impact factor: 5.372
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  1 in total

1.  Metformin normalizes type 2 diabetes-induced decrease in cell proliferation and neuroblast differentiation in the rat dentate gyrus.

Authors:  In Koo Hwang; Il Yong Kim; Eun Jung Joo; Jae Hoon Shin; Ji Won Choi; Moo-Ho Won; Yeo Sung Yoon; Je Kyung Seong
Journal:  Neurochem Res       Date:  2010-04       Impact factor: 3.996
  1 in total

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