OBJECTIVE: The study was designed to elucidate regional brain metabolic changes according to a treatment and their relationship with neuropsychological performance changes in obsessive-compulsive disorder (OCD). METHOD: Cerebral glucose metabolic rates were repeatedly measured before and after treatment in 10 patients with OCD using [18F]-2-fluoro-deoxyglucose positron emission tomography (PET). They were compared on a voxel-basis, and the correlations were counted between the regional metabolic changes and the degree to improvement on the neuropsychological assessments. RESULTS: After treatment, the patients showed significant (P < 0.005, two-tailed) regional metabolic changes in multiple brain areas involving frontal-subcortical circuits and parietal-cerebellar networks. Especially, the metabolic changes of the putamen, the cerebellum, and the hippocampus were significantly correlated with the improvement of the immediate- and delayed-recall scores of the Rey-Osterrieth Complex Figure Test (RCFT). CONCLUSION: These results suggest a possibility that metabolic changes of frontal-subcortical and parietal-cerebellar circuit changes may underlie cognitive improvements in patients with OCD.
OBJECTIVE: The study was designed to elucidate regional brain metabolic changes according to a treatment and their relationship with neuropsychological performance changes in obsessive-compulsive disorder (OCD). METHOD: Cerebral glucose metabolic rates were repeatedly measured before and after treatment in 10 patients with OCD using [18F]-2-fluoro-deoxyglucose positron emission tomography (PET). They were compared on a voxel-basis, and the correlations were counted between the regional metabolic changes and the degree to improvement on the neuropsychological assessments. RESULTS: After treatment, the patients showed significant (P < 0.005, two-tailed) regional metabolic changes in multiple brain areas involving frontal-subcortical circuits and parietal-cerebellar networks. Especially, the metabolic changes of the putamen, the cerebellum, and the hippocampus were significantly correlated with the improvement of the immediate- and delayed-recall scores of the Rey-Osterrieth Complex Figure Test (RCFT). CONCLUSION: These results suggest a possibility that metabolic changes of frontal-subcortical and parietal-cerebellar circuit changes may underlie cognitive improvements in patients with OCD.
Authors: Richard J Macatee; Nicholas P Allan; Agnieszka Gajewska; Aaron M Norr; Amanda Medley Raines; Brian J Albanese; Joseph W Boffa; Norman B Schmidt; Jesse R Cougle Journal: Cognit Ther Res Date: 2015-08-15
Authors: Thomas Wobrock; Oliver Gruber; Andrew M McIntosh; Susanne Kraft; Anne Klinghardt; Harald Scherk; Wolfgang Reith; Thomas Schneider-Axmann; Stephen M Lawrie; Peter Falkai; Thomas William Moorhead Journal: Eur Arch Psychiatry Clin Neurosci Date: 2010-01-29 Impact factor: 5.270
Authors: Soon Beom Hong; Yong-Wook Shin; Sun Hyung Kim; So Young Yoo; Jong-Min Lee; In Young Kim; Sun I Kim; Jun Soo Kwon Journal: Eur Arch Psychiatry Clin Neurosci Date: 2007-04-26 Impact factor: 5.270
Authors: Antonio Mantovani; Simone Rossi; Bruce D Bassi; Helen B Simpson; Brian A Fallon; Sarah H Lisanby Journal: Psychiatry Res Date: 2013-09-21 Impact factor: 3.222