Literature DB >> 12662076

A simple, regioselective synthesis of 1,4-bis(tert-butoxycarbonylmethyl)- tetraazacyclododecane.

Cong Li1, Wing-Tak Wong.   

Abstract

A convenient synthetic route to 1,4-bis(tert-butoxycarbonylmethyl)tetraazacyclododecane (cyclen) (1) with high yield and excellent regioselectivity is described. Compound 1 reacted with a range of functionalized alkyl halides under two reaction conditions to give mono-N-alkylated 1,4-bis(tert-butoxycarbonylmethyl)tetraazacyclododecane (2-9) in good yield.

Entities:  

Year:  2003        PMID： 12662076     DOI： 10.1021/jo026436+

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  3 in total

1.  A comparative study of trans- and cis-isomers of a bone-seeking agent, DO2A2P.

Authors:  Guiyang Hao; Wei Liu; Gedaa Hassan; Orhan K Öz; Zoltan Kovacs; Xiankai Sun
Journal:  Bioorg Med Chem Lett       Date:  2014-12-13       Impact factor: 2.823

2.  High relaxivity magnetic resonance imaging contrast agents. Part 1. Impact of single donor atom substitution on relaxivity of serum albumin-bound gadolinium complexes.

Authors:  Stéphane Dumas; Vincent Jacques; Wei-Chuan Sun; Jeffrey S Troughton; Joel T Welch; Jaclyn M Chasse; Heribert Schmitt-Willich; Peter Caravan
Journal:  Invest Radiol       Date:  2010-10       Impact factor: 6.016

3.  Rapid synthesis of 1,7-bis(t-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane (DO2A-t-Bu ester).

Authors:  Lauren E Hopper; Matthew J Allen
Journal:  Tetrahedron Lett       Date:  2014-10-01       Impact factor: 2.415
  3 in total

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