Literature DB >> 25506095

Rapid synthesis of 1,7-bis(t-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane (DO2A-t-Bu ester).

Lauren E Hopper1, Matthew J Allen1.   

Abstract

A three-step route was used to synthesize 1,7-bis(t-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane (DO2A-t-Bu ester) from 1,4,7,10-tetraazacyclododecane (cyclen). The overall time of reaction was reduced from a combined ~56 h to 2.3 h with an overall yield comparable to previously reported methods.

Entities:  

Keywords:  DO2A-t-Bu Ester; cyclen; microwave; transfer hydrogenation

Year:  2014        PMID： 25506095      PMCID： PMC4261951          DOI： 10.1016/j.tetlet.2014.08.026

Source DB:  PubMed          Journal:  Tetrahedron Lett        ISSN： 0040-4039            Impact factor:   2.415


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