| Literature DB >> 12657262 |
Scott H Watterson1, T G Murali Dhar, Shelley K Ballentine, Zhongqi Shen, Joel C Barrish, Daniel Cheney, Catherine A Fleener, Katherine A Rouleau, Robert Townsend, Diane L Hollenbaugh, Edwin J Iwanowicz.
Abstract
The development of a series of novel indole-based inhibitors of 5'-inosine monophosphate dehydrogenase (IMPDH) is described. Various hydrogen bond acceptors at C-3 of the indole were explored. The synthesis and the structure-activity relationships (SARs) derived from in vitro studies are outlined.Entities:
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Year: 2003 PMID： 12657262 DOI： 10.1016/s0960-894x(03)00109-4
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823