Literature DB >> 12654997

A structural and primary sequence comparison of the viral RNA-dependent RNA polymerases.

Jeremy A Bruenn1.   

Abstract

A systematic bioinformatic approach to identifying the evolutionarily conserved regions of proteins has verified the universality of a newly described conserved motif in RNA-dependent RNA polymerases (motif F). In combination with structural comparisons, this approach has defined two regions that may be involved in unwinding double-stranded RNA (dsRNA) for transcription. One of these is the N-terminal portion of motif F and the second is a large insertion in motif F present in the RNA-dependent RNA polymerases of some dsRNA viruses.

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Year:  2003        PMID： 12654997      PMCID： PMC152793          DOI： 10.1093/nar/gkg277

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  104 in total

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