Literature DB >> 1265483

Inherited retinal dystrophy: primary defect in pigment epithelium determined with experimental rat chimeras.

R J Mullen, M M LaVail.   

Abstract

Chimeric rats were produced by the aggregation of embryos of the pinkeyed, retinal dystrophic RCS strain with those of pigmented, normal rats. In the mosaic eyes, patches of neural retina with abnormal and degenerated photoreceptors were present only opposite patches of nonpigmented, mutant pigment epithelium. This indicates that the retinal dystrophy gene acts in the pigment epithelial cell rather than in the photoreceptor cell.

Entities:  

Mesh：

Year:  1976        PMID： 1265483     DOI： 10.1126/science.1265483

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  122 in total

Review 1.  Management of inherited outer retinal dystrophies: present and future.

Authors:  N H Chong; A C Bird
Journal:  Br J Ophthalmol       Date:  1999-01       Impact factor: 4.638

Review 2.  Molecular ophthalmology: an update on animal models for retinal degenerations and dystrophies.

Authors:  F Hafezi; C Grimm; B C Simmen; A Wenzel; C E Remé
Journal:  Br J Ophthalmol       Date:  2000-08       Impact factor: 4.638

3.  A mutation of early photoreceptor development, mikre oko, reveals cell-cell interactions involved in the survival and differentiation of zebrafish photoreceptors.

Authors:  G Doerre; J Malicki
Journal:  J Neurosci       Date:  2001-09-01       Impact factor: 6.167

4.  Tyrosine-mutant AAV8 delivery of human MERTK provides long-term retinal preservation in RCS rats.

Authors:  Wen-Tao Deng; Astra Dinculescu; Qiuhong Li; Sanford L Boye; Jie Li; Marina S Gorbatyuk; Jijing Pang; Vince A Chiodo; Michael T Matthes; Douglas Yasumura; Li Liu; Fowzan S Alkuraya; Kang Zhang; Douglas Vollrath; Matthew M LaVail; William W Hauswirth
Journal:  Invest Ophthalmol Vis Sci       Date:  2012-04-06       Impact factor: 4.799

5.  In vivo imaging of the photoreceptor mosaic in retinal dystrophies and correlations with visual function.

Authors:  Stacey S Choi; Nathan Doble; Joseph L Hardy; Steven M Jones; John L Keltner; Scot S Olivier; John S Werner
Journal:  Invest Ophthalmol Vis Sci       Date:  2006-05       Impact factor: 4.799

Review 6.  The retinal pigment epithelium in health and disease.

Authors:  J R Sparrow; D Hicks; C P Hamel
Journal:  Curr Mol Med       Date:  2010-12       Impact factor: 2.222

7.  Optomotor and immunohistochemical changes in the juvenile S334ter rat.

Authors:  Trevor J McGill; Glen T Prusky; Gabriel Luna; Matthew M LaVail; Steven K Fisher; Geoffrey P Lewis
Journal:  Exp Eye Res       Date:  2012-10-01       Impact factor: 3.467

Review 8.  Circadian regulation in the retina: From molecules to network.

Authors:  Gladys Y-P Ko
Journal:  Eur J Neurosci       Date:  2018-10-24       Impact factor: 3.386

Review 9.  Primary cilia and dendritic spines: different but similar signaling compartments.

Authors:  Inna V Nechipurenko; David B Doroquez; Piali Sengupta
Journal:  Mol Cells       Date:  2013-09-16       Impact factor: 5.034

10.  Culture of rat retinal pigment epithelium.

Authors:  R B Edwards
Journal:  In Vitro       Date:  1977-05
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