Literature DB >> 12650991

Effects of the cannabinoid antagonists AM281 and AM630 on deprivation-induced intake in Lewis rats.

Nikolaus A Werner1, James E Koch.   

Abstract

Male Lewis rats (two groups of 10) received intracerebroventricular injections of either AM 630 (vehicle, 2.5, 5, 10 and 20 microg) or AM 281 (vehicle, 5, 10, 20 and 40 microg) following overnight food deprivation. The CB2 antagonist AM 630 failed to block deprivation-induced intake at 0.5, 1, 2, 4 and 6 h. The CB1 antagonist AM 281 significantly blocked intake following 20 microg (1 h) and 40 microg (1, 2, 4 and 6 h). Results are discussed with respect to cannabinoid receptor systems' involvement in ingestion and the differential pharmacological profiles of AM 630 and AM 281.

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Year:  2003        PMID： 12650991     DOI： 10.1016/s0006-8993(02)04274-9

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  21 in total

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Review 4.  [The endogenous cannabinoid system. Therapeutic implications for neurologic and psychiatric disorders].

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5.  Low dose naloxone attenuates the pruritic but not anorectic response to rimonabant in male rats.

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6.  The role of central CB2 cannabinoid receptors on food intake in neonatal chicks.

Authors:  L Emadi; H Jonaidi; E Hosseini Amir Abad
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7.  Inverse agonism of cannabinoid CB1 receptors potentiates LiCl-induced nausea in the conditioned gaping model in rats.

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8.  Interrelationship of CB1R and OBR pathways in regulation of metabolic, neuroendocrine, and behavioral responses to food restriction and voluntary wheel running.

Authors:  Abdoulaye Diane; Donna F Vine; James C Russell; C Donald Heth; W David Pierce; Spencer D Proctor
Journal:  J Appl Physiol (1985)       Date:  2014-06-05

9.  Behavioral effects of CB2 cannabinoid receptor activation and its influence on food and alcohol consumption.

Authors:  E S Onaivi; O Carpio; H Ishiguro; N Schanz; G R Uhl; R Benno
Journal:  Ann N Y Acad Sci       Date:  2008-10       Impact factor: 5.691

10.  TASK1 modulates inflammation and neurodegeneration in autoimmune inflammation of the central nervous system.

Authors:  Stefan Bittner; Sven G Meuth; Kerstin Göbel; Nico Melzer; Alexander M Herrmann; Ole J Simon; Andreas Weishaupt; Thomas Budde; Douglas A Bayliss; Martin Bendszus; Heinz Wiendl
Journal:  Brain       Date:  2009-07-01       Impact factor: 13.501
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