Literature DB >> 12646152

Receptor sensitivity: when T cells lose their sense of self.

Kristin A Hogquist1, Timothy K Starr, Stephen C Jameson.   

Abstract

The T-cell antigen receptor binds to self-MHC molecules with low affinity. Recent reports disagree as to whether this interaction sensitizes or desensitizes the receptor. Here we discuss how these findings might be reconciled.

Mesh：

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Year:  2003        PMID： 12646152     DOI： 10.1016/s0960-9822(03)00161-1

Source DB:  PubMed          Journal:  Curr Biol        ISSN： 0960-9822            Impact factor:   10.834


  11 in total

Review 1.  The double life of a B-1 cell: self-reactivity selects for protective effector functions.

Authors:  Nicole Baumgarth
Journal:  Nat Rev Immunol       Date:  2010-12-10       Impact factor: 53.106

Review 2.  Quantitative challenges in understanding ligand discrimination by alphabeta T cells.

Authors:  Ofer Feinerman; Ronald N Germain; Grégoire Altan-Bonnet
Journal:  Mol Immunol       Date:  2007-09-06       Impact factor: 4.407

Review 3.  mTOR and other effector kinase signals that impact T cell function and activity.

Authors:  Darienne R Myers; Benjamin Wheeler; Jeroen P Roose
Journal:  Immunol Rev       Date:  2019-09       Impact factor: 12.988

4.  Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells.

Authors:  Darienne R Myers; Tannia Lau; Evan Markegard; Hyung W Lim; Herbert Kasler; Minghua Zhu; Andrea Barczak; John P Huizar; Julie Zikherman; David J Erle; Weiguo Zhang; Eric Verdin; Jeroen P Roose
Journal:  Cell Rep       Date:  2017-05-23       Impact factor: 9.423

5.  Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection.

Authors:  Jeremy Juang; Peter J R Ebert; Dan Feng; K Christopher Garcia; Michelle Krogsgaard; Mark M Davis
Journal:  J Exp Med       Date:  2010-05-10       Impact factor: 14.307

6.  The activation threshold of CD4+ T cells is defined by TCR/peptide-MHC class II interactions in the thymic medulla.

Authors:  Tom Li Stephen; Anastasia Tikhonova; Janice M Riberdy; Terri M Laufer
Journal:  J Immunol       Date:  2009-11-01       Impact factor: 5.422

7.  MHC-dependent desensitization of intrinsic anti-self reactivity.

Authors:  Cristan M Jubala; Angela R Lamerato-Kozicki; Michelle Borakove; Julie Lang; Lori A Gardner; David Coffey; Karen M Helm; Jerome Schaack; Monika Baier; Gary R Cutter; Donald Bellgrau; Jaime F Modiano
Journal:  Cancer Immunol Immunother       Date:  2008-06-04       Impact factor: 6.968

8.  Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression.

Authors:  Evan Markegard; Evan Trager; Chih-wen Ou Yang; Weiguo Zhang; Arthur Weiss; Jeroen P Roose
Journal:  PLoS One       Date:  2011-09-26       Impact factor: 3.240

9.  Self-class I MHC molecules support survival of naive CD8 T cells, but depress their functional sensitivity through regulation of CD8 expression levels.

Authors:  Kensuke Takada; Stephen C Jameson
Journal:  J Exp Med       Date:  2009-09-14       Impact factor: 14.307

10.  Low ligand requirement for deletion and lack of synapses in positive selection enforce the gauntlet of thymic T cell maturation.

Authors:  Peter J R Ebert; Lauren I Richie Ehrlich; Mark M Davis
Journal:  Immunity       Date:  2008-11-14       Impact factor: 31.745
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