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Literature DB >> 21151033

The double life of a B-1 cell: self-reactivity selects for protective effector functions.

Abstract

During their development, B and T cells with self-reactive antigen receptors are generally deleted from the repertoire to avoid autoimmune diseases. Paradoxically, innate-like B-1 cells in mice are positively selected for self-reactivity and form a pool of long-lived, self-renewing B cells that produce most of the circulating natural IgM antibodies. This Review provides an overview of the developmental processes that shape the B-1 cell pool in mice, outlines the functions of B-1 cells in both the steady state and during host defence, and discusses possible functional B-1 cell homologues that exist in humans.

Entities: Disease Species

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Year: 2010 PMID： 21151033 DOI： 10.1038/nri2901

Source DB: PubMed Journal: Nat Rev Immunol ISSN： 1474-1733 Impact factor: 53.106

149 in total

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409 in total

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Journal: Proc Natl Acad Sci U S A Date: 2012-03-14 Impact factor: 11.205

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8. FcμR in human B cell subsets in primary selective IgM deficiency, and regulation of FcμR and production of natural IgM antibodies by IGIV.

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9. Lactoferrin causes IgA and IgG2b isotype switching through betaglycan binding and activation of canonical TGF-β signaling.

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10. Sensing Microbial Viability through Bacterial RNA Augments T Follicular Helper Cell and Antibody Responses.

Authors: Gaetan Barbet; Leif E Sander; Matthew Geswell; Irina Leonardi; Andrea Cerutti; Iliyan Iliev; J Magarian Blander
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