| Literature DB >> 12646018 |
Yong-Qian Wu1, Sergei Belyakov, Chi Choi, David Limburg, Bert E Thomas IV, Mark Vaal, Ling Wei, Douglas E Wilkinson, Agnes Holmes, Mike Fuller, Jocelyn McCormick, Maureen Connolly, Tim Moeller, Joseph Steiner, Gregory S Hamilton.
Abstract
Peptidylprolyl isomerase cyclophilins play critical roles in a variety of biological processes. Recent findings that cyclophilins are present at high levels in the CNS and that cyclosporin A may possess neuroprotective/neurotrophic effects have prompted us to search for nonimmunosuppressant small molecule cyclophilin ligands. To this end, we report the lead identification through "virtual screening" and the synthesis of our first series of non-peptidic cyclophilin ligands, along with the preliminary biological results.Entities:
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Year: 2003 PMID： 12646018 DOI： 10.1021/jm020409u
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446