Literature DB >> 12643918

N-Alkoxysulfamide, N-hydroxysulfamide, and sulfamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases.

Jeewoo Lee1, Sung Eun Kim, Ji Young Lee, Su Yeon Kim, Sang Uk Kang, Seung Hwan Seo, Moon Woo Chun, Taehee Kang, Soo Young Choi, Hea Ok Kim.   

Abstract

A series of sulfamate surrogates of methionyl and isoleucyl adenylate have been investigated as MetRS and IleRS inhibitors by modifications of the sulfamate linker and adenine moieties. The discovery of 2-iodo Ile-NHSO(2)-AMP (58) as a potent Escherichia coli IleRS inhibitor revealed that a significant hydrophobic interaction between the 2-substituent of Ile-NHSO(2)-AMP and the adenine binding site of IleRS provided its high potency to the enzyme.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 12643918     DOI： 10.1016/s0960-894x(03)00020-9

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  IA, database of known ligands of aminoacyl-tRNA synthetases.

Authors:  Mieczyslaw Torchala; Marcin Hoffmann
Journal:  J Comput Aided Mol Des       Date:  2007-09-20       Impact factor: 3.686

2.  Discovering new classes of Brugia malayi asparaginyl-tRNA synthetase inhibitors and relating specificity to conformational change.

Authors:  Sai Chetan K Sukuru; Thibaut Crepin; Youli Milev; Liesl C Marsh; Jonathan B Hill; Regan J Anderson; Jonathan C Morris; Anjali Rohatgi; Gavin O'Mahony; Morten Grøtli; Franck Danel; Malcolm G P Page; Michael Härtlein; Stephen Cusack; Michael A Kron; Leslie A Kuhn
Journal:  J Comput Aided Mol Des       Date:  2006-04-28       Impact factor: 3.686

3.  Synthesis and Biological Evaluation of Lipophilic Nucleoside Analogues as Inhibitors of Aminoacyl-tRNA Synthetases.

Authors:  Manesh Nautiyal; Bharat Gadakh; Steff De Graef; Luping Pang; Masroor Khan; Yi Xun; Jef Rozenski; Arthur Van Aerschot
Journal:  Antibiotics (Basel)       Date:  2019-10-09

4.  Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors.

Authors:  Baole Zhang; Luping Pang; Manesh Nautiyal; Steff De Graef; Bharat Gadakh; Eveline Lescrinier; Jef Rozenski; Sergei V Strelkov; Stephen D Weeks; Arthur Van Aerschot
Journal:  Molecules       Date:  2020-10-16       Impact factor: 4.411
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.