Literature DB >> 12643603

In vivo assessment of angioarchitecture and microcirculation in experimental liver cancer: a new model in rats.

S M Maksan1, H Paulo, E Ryschich, C Kuntz, M M Gebhard, E Klar, J Schmidt.   

Abstract

The rising incidence of unresectable hepatocellular malignancies remains a therapeutic challenge. Little is known about the mechanisms of angiogenesis and immunological aspects of liver tumor vessels. The aim of this study was to investigate hepatic and tumor microcirculation and leukocyte-endothelium interaction by means of intravital microscopy in a rat model of hepatocellular carcinoma. Off-line analysis showed that the angioarchitecture as well as blood flow velocity in liver cancer is heterogeneous. The leukocyte-endothelium interaction is significantly reduced compared to normal liver tissue. The data suggest that the main mechanism is a reduced expression of adhesion molecules demonstrating an effective immune escape mechanism of this tumor. The model represents a useful experimental tool to explore angiogenesis inhibition or immunological therapeutic strategies in experimental liver cancer.

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Year:  2003        PMID： 12643603     DOI： 10.1023/a:1021919224972

Source DB:  PubMed          Journal:  Dig Dis Sci        ISSN： 0163-2116            Impact factor:   3.199


  50 in total

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  6 in total

1.  Enhancement of leukocyte adhesion after percutaneous irradiation in rats with hepatocellular carcinoma.

Authors:  Sasa-Marcel Maksan; Eduard Schmidt; Eduard Ryschich; Wolfgang Harms; Jan Schmidt
Journal:  World J Gastroenterol       Date:  2005-04-07       Impact factor: 5.742

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Authors:  Charlotte Debbaut; Patrick Segers; Pieter Cornillie; Christophe Casteleyn; Manuel Dierick; Wim Laleman; Diethard Monbaliu
Journal:  J Anat       Date:  2014-01-17       Impact factor: 2.610

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Journal:  Surg Endosc       Date:  2004-11-11       Impact factor: 4.584

4.  Immune escape mechanism: defective resting and stimulated leukocyte-endothelium interaction in hepatocellular carcinoma of the rat.

Authors:  Sasa-Marcel Maksan; Patrick Morad Araib; Eduard Ryschich; Martha Maria Gebhard; Jan Schmidt
Journal:  Dig Dis Sci       Date:  2004-05       Impact factor: 3.199

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Authors:  Eduard Ryschich; Eduard Schmidt; Sasa-Marcel Maksan; Ernst Klar; Jan Schmidt
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Journal:  World J Gastroenterol       Date:  2004-03-01       Impact factor: 5.742
  6 in total

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