AIM: To evaluate the effects of percutaneous radiation on leukocyte-endothelium interaction (LEI) in experimental hepatocellular carcinoma (HCC). METHODS: Twelve ACI rats underwent HCC-inoculation, six of which on day 12 received low-dose external radiation and six did not. After 12 h intravital microscopy was performed. RESULTS: LEI was significantly reduced in tumor tissue. However, irradiation of liver sinusoids and tumor tissue with 6 Gy led to a significant activation of leukocyte adhesion in the tumor with a marked increase of the proinflammatory cytokine TNF-alpha. CONCLUSION: The findings indicate that the immunological tumor-endothelial barrier can be overcome by external irradiation.
AIM: To evaluate the effects of percutaneous radiation on leukocyte-endothelium interaction (LEI) in experimental hepatocellular carcinoma (HCC). METHODS: Twelve ACI rats underwent HCC-inoculation, six of which on day 12 received low-dose external radiation and six did not. After 12 h intravital microscopy was performed. RESULTS: LEI was significantly reduced in tumor tissue. However, irradiation of liver sinusoids and tumor tissue with 6 Gy led to a significant activation of leukocyte adhesion in the tumor with a marked increase of the proinflammatory cytokine TNF-alpha. CONCLUSION: The findings indicate that the immunological tumor-endothelial barrier can be overcome by external irradiation.
Authors: Jason Chia-Hsien Cheng; Jian Kuen Wu; Chao Ming Huang; David Y Huang; Skye H Cheng; Yu Mong Lin; James J Jian; Po Sheng Yang; Vincent P Chuang; Andrew T Huang Journal: Radiother Oncol Date: 2002-04 Impact factor: 6.280
Authors: J Chia-Hsien Cheng; V P Chuang; S H Cheng; Y M Lin; T I Cheng; P S Yang; J J Jian; D L You; C F Horng; A T Huang Journal: Int J Cancer Date: 2001-08-20 Impact factor: 7.396
Authors: K Tokuuye; M Sumi; Y Kagami; S Murayama; M Kawashima; H Ikeda; H Ueno; T Okusaka; S Okada Journal: Strahlenther Onkol Date: 2000-09 Impact factor: 3.621