| Literature DB >> 1264220 |
J M Armstrong, G J Blackwell, R J Flower, J C McGiff, K M Mullane, J R Vane.
Abstract
Noradrenaline releases prostaglandins in the kidney, and in rats these augment rather than reduce vasoconstriction produced by the amine. Homogenates of kidneys of New Zealand rats inbred for hypertension exhibit lower prostaglandin inactivation by 15-hydroxydehydrogenase than controls. At the same time, augmentation of noradrenaline vasoconstriction by the released prostaglandin is exaggerated. This biochemical defect could be the inherited abnormality primarily responsible for the development of hypertension in these animals.Entities:
Mesh：
Substances：
Year: 1976 PMID： 1264220 DOI： 10.1038/260582a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962