Inhalant abuse in the pediatric population: a persistent challenge.

Inhalants remain one of the most commonly abused substances by adolescents in the United States today. Recent epidemiologic studies have demonstrated a decrease in the prevalence of inhalant abuse, but overall rates remain high. Inhalants have the potential to result in serious organ system dysfunction or even sudden death. This article reviews the most recent epidemiologic data on inhalant abuse, summarizes the types of substances used and their mechanism of actions, and discusses clinical toxicity and medical management.