OBJECTIVE: To assess left ventricular remodelling in patients with reperfused acute myocardial infarction and to study its relation to microvascular damage. PATIENTS: 25 patients successfully treated by primary percutaneous coronary angioplasty for acute myocardial infarction. SETTING: University hospital METHODS: Indexed end diastolic (EDVi) and end systolic (ESVi) volumes were assessed on admission and repeated at days 1 and 8. Coronary flow reserve (CFR) was assessed in the infarct related artery on day 1. Myocardial blood volume was assessed on admission and at day 8 by myocardial contrast echocardiography. In patients who manifested persistent myocardial dysfunction at hospital discharge (n = 21), local inotropic reserve was assessed by dobutamine echocardiography at day 7. RESULTS: On admission, patients with and without local viability had similar EDVi and ESVi (EDVi 67 (9) and 73 (14) ml/m(2), respectively; ESVi 34 (8) and 40 (11) ml/m(2), respectively; NS). EDVi increased to 97 (22) ml/m(2) in patients without local viability (p < 0.01 v admission) but remained unchanged at 70 (11) ml/m(2) in patients with viable myocardium (NS v admission). For pooled patient data, the percentage change in EDVi correlated with CFR (r = 0.76, p < 0.0001) and myocardial blood volume in the infarct territory (r = 0.80, p < 0.0001). CONCLUSION: Left ventricular dilatation may preferably occur in patients without local viability and is correlated with early CFR and extent of myocardial blood volume in the infarct territory.
OBJECTIVE: To assess left ventricular remodelling in patients with reperfused acute myocardial infarction and to study its relation to microvascular damage. PATIENTS: 25 patients successfully treated by primary percutaneous coronary angioplasty for acute myocardial infarction. SETTING: University hospital METHODS: Indexed end diastolic (EDVi) and end systolic (ESVi) volumes were assessed on admission and repeated at days 1 and 8. Coronary flow reserve (CFR) was assessed in the infarct related artery on day 1. Myocardial blood volume was assessed on admission and at day 8 by myocardial contrast echocardiography. In patients who manifested persistent myocardial dysfunction at hospital discharge (n = 21), local inotropic reserve was assessed by dobutamine echocardiography at day 7. RESULTS: On admission, patients with and without local viability had similar EDVi and ESVi (EDVi 67 (9) and 73 (14) ml/m(2), respectively; ESVi 34 (8) and 40 (11) ml/m(2), respectively; NS). EDVi increased to 97 (22) ml/m(2) in patients without local viability (p < 0.01 v admission) but remained unchanged at 70 (11) ml/m(2) in patients with viable myocardium (NS v admission). For pooled patient data, the percentage change in EDVi correlated with CFR (r = 0.76, p < 0.0001) and myocardial blood volume in the infarct territory (r = 0.80, p < 0.0001). CONCLUSION: Left ventricular dilatation may preferably occur in patients without local viability and is correlated with early CFR and extent of myocardial blood volume in the infarct territory.
Authors: J L Monin; J Garot; M Scherrer-Crosbie; J Rosso; A M Duval-Moulin; P Dupouy; E Teiger; A Castaigne; J C Cachin; J L Dubois-Rande; P Gueret Journal: J Am Coll Cardiol Date: 1999-10 Impact factor: 24.094
Authors: L De Luca; G Sardella; C J Davidson; G De Persio; M Beraldi; T Tommasone; M Mancone; B L Nguyen; L Agati; M Gheorghiade; F Fedele Journal: Heart Date: 2005-10-26 Impact factor: 5.994
Authors: William Hiesinger; Jose Manuel Perez-Aguilar; Pavan Atluri; Nicole A Marotta; John R Frederick; J Raymond Fitzpatrick; Ryan C McCormick; Jeffrey R Muenzer; Elaine C Yang; Rebecca D Levit; Li-Jun Yuan; John W Macarthur; Jeffery G Saven; Y Joseph Woo Journal: Circulation Date: 2011-09-13 Impact factor: 29.690
Authors: William Hiesinger; Sergei A Vinogradov; Pavan Atluri; J Raymond Fitzpatrick; John R Frederick; Rebecca D Levit; Ryan C McCormick; Jeffrey R Muenzer; Elaine C Yang; Nicole A Marotta; John W MacArthur; David F Wilson; Y Joseph Woo Journal: J Appl Physiol (1985) Date: 2011-02-03
Authors: M Remmelink; K D Sjauw; Z Y Yong; J D E Haeck; M M Vis; K T Koch; J G P Tijssen; R J de Winter; J P S Henriques; J J Piek; J Baan Journal: Neth Heart J Date: 2013-05 Impact factor: 2.380