Literature DB >> 12639566

A structure-permeability study of small drug-like molecules.

Thomas Fichert1, Mehran Yazdanian, John R Proudfoot.   

Abstract

A systematic structure-permeability relationship study on a set of small drug-like molecules with log D values in the range -2.5 to 3 and carrying a diverse array of functionality reveals that the compounds with log D>0 and <3 are highly permeable. Surprisingly, several tetrazole derivatives were found to be substrates for efflux pump(s).

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Year:  2003        PMID： 12639566     DOI： 10.1016/s0960-894x(02)01035-1

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  15 in total

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