Literature DB >> 12639549

Inhibition of inosine monophosphate dehydrogenase (IMPDH) by 2-[2-(Z)-fluorovinyl]inosine 5'-monophosphate.

Vasu Nair1, Ramesh C Kamboj.   

Abstract

Inosine 5'-monophosphate dehydrogenase (IMPDH; EC 1.1.1.205) isolated from Escherichia coli B3 cells was strongly inhibited by 2-[2-(Z)-fluorovinyl]inosine 5'-monophosphate (2-FVIMP). Inhibition of IMPDH appears to be irreversible with k(inact) and K(i) values of 0.0269 s(-1) and 1.11 microM, respectively.

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Year:  2003        PMID： 12639549     DOI： 10.1016/s0960-894x(02)01053-3

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

Review 1.  IMP dehydrogenase: structure, mechanism, and inhibition.

Authors:  Lizbeth Hedstrom
Journal:  Chem Rev       Date:  2009-07       Impact factor: 60.622

2.  A heterocyclic molecule with significant activity against dengue virus.

Authors:  Vasu Nair; Guochen Chi; Qingning Shu; Justin Julander; Donald F Smee
Journal:  Bioorg Med Chem Lett       Date:  2009-01-15       Impact factor: 2.823

3.  Repurposing existing drugs: identification of irreversible IMPDH inhibitors by high-throughput screening.

Authors:  Albertus Eka Yudistira Sarwono; Shinya Mitsuhashi; Mohammad Hazzaz Bin Kabir; Kengo Shigetomi; Tadashi Okada; Fumina Ohsaka; Satoko Otsuguro; Katsumi Maenaka; Makoto Igarashi; Kentaro Kato; Makoto Ubukata
Journal:  J Enzyme Inhib Med Chem       Date:  2019-12       Impact factor: 5.051
  3 in total

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