| Literature DB >> 12639541 |
Sang-sup Jew1, Boon-saeng Park, Doo-yeon Lim, Myoung Goo Kim, In Kwon Chung, Joo Hee Kim, Chung Il Hong, Joon-Kyum Kim, Hong-Jun Park, Jun-Hee Lee, Hyeung-geun Park.
Abstract
Twenty-one pyridine-2-carboxylate derivatives were prepared by the coupling of 6-formyl-2-carboxylic acid with the corresponding phenol, thiophenol, and aniline, substituted with various functional groups. Among them, the 3,4-dichlorothiophenol ester (9p) showed the highest in vitro telomerase inhibitory activity and quite significant in vivo tumor suppression activity.Entities:
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Year: 2003 PMID： 12639541 DOI： 10.1016/s0960-894x(02)01041-7
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823