Literature DB >> 12639538

Pyridazinones as selective cyclooxygenase-2 inhibitors.

Chun Sing Li1, Christine Brideau, Chi Chung Chan, Chantal Savoie, David Claveau, Stella Charleson, Robert Gordon, Gillian Greig, Jacques Yves Gauthier, Cheuk K Lau, Denis Riendeau, Michel Thérien, Elizabeth Wong, Petpiboon Prasit.   

Abstract

Pyridazinone was found to be an excellent core template for selective COX-2 inhibitors. Two potent, selective and orally active COX-2 inhibitors, which were highly efficacious in rat paw edema and rat pyresis models, have been obtained.

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Year:  2003        PMID： 12639538     DOI： 10.1016/s0960-894x(02)01045-4

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  Free energy perturbation approach to the critical assessment of selective cyclooxygenase-2 inhibitors.

Authors:  Hwangseo Park; Sangyoub Lee
Journal:  J Comput Aided Mol Des       Date:  2005-01       Impact factor: 3.686

2.  Pyridazines. Part 37: Facile solution phase combinatorial synthesis of highly substituted pyridazin-3-ones.

Authors:  Eddy Sotelo
Journal:  Mol Divers       Date:  2004       Impact factor: 2.943

3.  Utility of novel 2-furanones in synthesis of other heterocyclic compounds having anti-inflammatory activity with dual COX2/LOX inhibition.

Authors:  Rania H Abd El-Hameed; Shahenda Mahgoub; Hend M El-Shanbaky; Mosaad S Mohamed; Sahar A Ali
Journal:  J Enzyme Inhib Med Chem       Date:  2021-12       Impact factor: 5.051

4.  Selective COX-2 Inhibitors: A Review of Their Structure-Activity Relationships.

Authors:  Afshin Zarghi; Sara Arfaei
Journal:  Iran J Pharm Res       Date:  2011       Impact factor: 1.696

5.  Design, synthesis, molecular modeling and biological evaluation of novel diaryl heterocyclic analogs as potential selective cyclooxygenase-2 (COX-2) inhibitors.

Authors:  Deema A Al-Turki; Mohamed A Al-Omar; Laila A Abou-Zeid; Ihsan A Shehata; Mohammed S Al-Awady
Journal:  Saudi Pharm J       Date:  2015-07-26       Impact factor: 4.330
  5 in total

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