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Literature DB >> 1263757

Inhibition of cholesterol absorption by (-)N-[alpha-phenyl-beta-(p-tolyl)ethyl] linoleamide in rats.

Abstract

The effect of (-)N-[alpha-phenyl-beta-(p-tolyl)ethyl] linoleamide (PTLA) on intestinal absorption of cholesterol was studied in rats. Oral administration of 15 mg PTLA to rats resulted in a significant (P less than 0.05) decrease in the radioactivity in serum and liver 4 hr after administration of labeled cholesterol. The effect of PTLA was greater on the absorption of cholesteryl oleate as compared with free cholesterol. The rate of hydrolysis of cholesteryl oleate in mucosal homogenates of rat intestine was decreased with PTLA, suggesting that the inhibition of cholesterol absorption by PTLA is related to its effect on cholesteryl ester hydrolysis in the intestine.

Entities: Chemical Species

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Year: 1976 PMID： 1263757 DOI： 10.1007/BF02532852

Source DB: PubMed Journal: Lipids ISSN： 0024-4201 Impact factor: 1.880

8 in total

1. ROLE OF BILE AND PANCREATIC JUICE IN CHOLESTEROL ABSORPTION AND ESTERIFICATION.

Authors: C R BORJA; G V VAHOUNY; C R TREADWELL
Journal: Am J Physiol Date: 1964-01

2. Enzymic preparation of labeled unsaturated fatty acid esters of cholesterol.

Authors: L SWELL; C R TREADWELL
Journal: Anal Biochem Date: 1962-10 Impact factor: 3.365

3. The effect of N-(alpha-methylbenzyl) linoleamide on cholesterol metabolism in rats.

Authors: H Fukushima; S Aono; Y Nakamura; M Endo; T Imai
Journal: J Atheroscler Res Date: 1969 Nov-Dec

4. The effect of N-cyclohexyl linoleamide on experimental atherosclerosis in rabbits.

Authors: H Nakatani
Journal: Jpn J Pharmacol Date: 1966-12

5. The effect of (--)N-(alpha-phenyl-beta-(p-tolyl)ethyl) linoleamide on experimental atherosclerosis in rabbits.

Authors: H Nakatani; S Aono; Y Suzuki; H Fukushima; Y Nakamura
Journal: Atherosclerosis Date: 1970 Sep-Oct Impact factor: 5.162

6. Effect of (-)N-[alpha-phenyl-beta-(p-tolyl)ethyl] linoleamide on lipid levels in serum and liver in cholesterol-fed rats.

Authors: A Nagata; S Aono; H Nakatani
Journal: Lipids Date: 1976-03 Impact factor: 1.880

7. N-cyclohexyl linoleamide: metabolism and cholesterol-lowering effect in rats.

Authors: H Nakatani; H Fukushima; A Wakimura; M Endo
Journal: Science Date: 1966-09-09 Impact factor: 47.728

8. Role of the intestinal brush border in the absorption of cholesterol in rats.

Authors: J S David; P Malathi; J Ganguly
Journal: Biochem J Date: 1966-03 Impact factor: 3.857