| Literature DB >> 12630869 |
D K Barma1, Abhijit Kundu, Hongming Zhang, Charles Mioskowski, J R Falck.
Abstract
(Z)-alpha-Fluoro-, (Z)-alpha-chloro-, and (Z)-alpha-bromoacrylates were obtained with unprecedented yield and stereocontrol (>99%) via addition of the corresponding commercial trihaloacetates to aldehydes at room temperature using stoichiometric Cr(II) salts or catalytic Cr(II) with a regeneration system. The intermediate 2,2-dihalo-3-hydroxy adducts could be isolated in good yields under conditions of limited reagent at 0 degrees C.Entities:
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Year: 2003 PMID： 12630869 DOI： 10.1021/ja029938d
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419