Literature DB >> 12628677

In vitro antifungal activity of new series of homoallylamines and related compounds with inhibitory properties of the synthesis of fungal cell wall polymers.

Leonor Y Vargas M1, María V Castelli, Vladimir V Kouznetsov, Juan M Urbina G, Silvia N López, Maximiliano Sortino, Ricardo D Enriz, Juan C Ribas, Susana Zacchino.   

Abstract

The synthesis, in vitro antifungal evaluation and SAR studies of 101 compounds of the 4-aryl-, 4-alkyl-, 4-pyridyl or -quinolinyl-4-N-arylamino-1-butenes series and related compounds, are reported here. Active structures showed to inhibit (1,3)-beta-D-glucan and mainly chitin synthases, enzymes that catalyze the synthesis of the major fungal cell wall polymers.

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Year:  2003        PMID： 12628677     DOI： 10.1016/s0968-0896(02)00605-3

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  8 in total

1.  Palladium-catalyzed allylic substitution with (η6-arene-CH2Z)Cr(CO)(3)-based nucleophiles.

Authors:  Jiadi Zhang; Corneliu Stanciu; Beibei Wang; Mahmud M Hussain; Chao-Shan Da; Patrick J Carroll; Spencer D Dreher; Patrick J Walsh
Journal:  J Am Chem Soc       Date:  2011-11-29       Impact factor: 15.419

2.  The development of Friedländer heteroannulation through a single electron transfer and energy transfer pathway using methylene blue (MB+).

Authors:  Farzaneh Mohamadpour
Journal:  Sci Rep       Date:  2022-05-04       Impact factor: 4.996

3.  Antibacterial and Antioxidant Properties of the Methanolic Extract of the Stem Bark of Pteleopsis hylodendron (Combretaceae).

Authors:  Aristide Laurel Mokale Kognou; Rosalie Annie Ngono Ngane; Jules Roger Kuiate; Martin Luther Koanga Mogtomo; Alembert Tchinda Tiabou; Raymond Simplice Mouokeu; Lucie Biyiti; Paul Henri Amvam Zollo
Journal:  Chemother Res Pract       Date:  2011-03-03

4.  Structural and spectral investigations of the recently synthesized chalcone (E)-3-mesityl-1-(naphthalen-2-yl) prop-2-en-1-one, a potential chemotherapeutic agent.

Authors:  Assem Barakat; Abdullah Mohammed Al-Majid; Saied M Soliman; Yahia Nasser Mabkhot; M Ali; Hazem A Ghabbour; Hoong-Kun Fun; Abdul Wadood
Journal:  Chem Cent J       Date:  2015-06-13       Impact factor: 4.215

5.  Investigating the activity spectrum for ring-substituted 8-hydroxyquinolines.

Authors:  Robert Musiol; Josef Jampilek; Jacek E Nycz; Matus Pesko; James Carroll; Katarina Kralova; Marcela Vejsova; Jim O'Mahony; Aidan Coffey; Anna Mrozek; Jaroslaw Polanski
Journal:  Molecules       Date:  2010-01-12       Impact factor: 4.411

6.  Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives.

Authors:  Vladímir V Kouznetsov; Susana A Zacchino; Maximiliano Sortino; Leonor Y Vargas Méndez; Mahabir P Gupta
Journal:  Sci Pharm       Date:  2012-10-23

7.  Structural requirements for the antifungal activities of natural drimane sesquiterpenes and analogues, supported by conformational and electronic studies.

Authors:  Marcos Derita; Iván Montenegro; Francisco Garibotto; Ricardo D Enriz; Mauricio Cuellar Fritis; Susana A Zacchino
Journal:  Molecules       Date:  2013-02-05       Impact factor: 4.411

8.  Ring-substituted 4-hydroxy-1H-quinolin-2-ones: preparation and biological activity.

Authors:  Josef Jampilek; Robert Musiol; Matus Pesko; Katarina Kralova; Marcela Vejsova; James Carroll; Aidan Coffey; Jacek Finster; Dominik Tabak; Halina Niedbala; Violetta Kozik; Jaroslaw Polanski; Jozef Csollei; Jiri Dohnal
Journal:  Molecules       Date:  2009-03-13       Impact factor: 4.411
  8 in total

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