Danijel Zerdoner1. 1. Department of Maxillofacial and Oral Surgery, Hospital Celje, Slovenia. danijel.zerdoner@guest.arnes.si
Abstract
INTRODUCTION: The diagnosis, prognosis and treatment of particular pathologic entities of the oral mucosa depend almost exclusively on the histologic changes in the epithelium. The basis for the classification of oral epithelial hyperplastic lesions should be their propensity to progress to invasive cancer. MATERIAL AND METHODS: In a retrospective study, 135 biopsies of oral epithelial hyperplastic lesions from 115 patients were classified according to the Ljubljana classification, which has recently been introduced for the grading of laryngeal hyperplastic epithelial lesions. RESULTS: Seventy nine cases (59%) showed simple, 42 (31%) abnormal and 11 (8%) atypical hyperplasia; carcinoma in situ was found in three cases (2%). During the follow-up, ranging from 3 months to 6 years (median 1 year), two cases of atypical hyperplasia progressed to invasive cancer, whereas none of the cases classified as simple or abnormal hyperplasia showed progression. CONCLUSION: The present study suggests that the Ljubljana classification can be reliably applied for classifying oral epithelial hyperplastic lesions into different risk groups, which is essential for prognosis in order to plan therapy.
INTRODUCTION: The diagnosis, prognosis and treatment of particular pathologic entities of the oral mucosa depend almost exclusively on the histologic changes in the epithelium. The basis for the classification of oral epithelial hyperplastic lesions should be their propensity to progress to invasive cancer. MATERIAL AND METHODS: In a retrospective study, 135 biopsies of oral epithelial hyperplastic lesions from 115 patients were classified according to the Ljubljana classification, which has recently been introduced for the grading of laryngeal hyperplastic epithelial lesions. RESULTS: Seventy nine cases (59%) showed simple, 42 (31%) abnormal and 11 (8%) atypical hyperplasia; carcinoma in situ was found in three cases (2%). During the follow-up, ranging from 3 months to 6 years (median 1 year), two cases of atypical hyperplasia progressed to invasive cancer, whereas none of the cases classified as simple or abnormal hyperplasia showed progression. CONCLUSION: The present study suggests that the Ljubljana classification can be reliably applied for classifying oral epithelial hyperplastic lesions into different risk groups, which is essential for prognosis in order to plan therapy.
Authors: Leni Verônica de Oliveira Silva; José Alcides Almeida de Arruda; Lucas Guimarães Abreu; Raquel Conceição Ferreira; Leorik Pereira da Silva; Cibele Pelissari; Ricardo Natã Fonseca Silva; Kaio Heide Sampaio Nóbrega; Bruno Augusto Benevenuto de Andrade; Mario José Romañach; Michelle Agostini; Cassiano Francisco Weege Nonaka; Pollianna Muniz Alves; Hélder Antônio Rebelo Pontes; Luís Fernando Rivero; Lélia Batista de Souza; Marília Trierveiler; Elismauro Francisco Mendonça; Ana Paula Neutzling Gomes; Manoela Domingues Martins; Emanuel Sávio de Souza Andrade; Marcia Maria Fonseca da Silveira; Ana Paula Veras Sobral; Ricardo Alves Mesquita Journal: Head Neck Pathol Date: 2020-02-19