| Literature DB >> 12620325 |
Makoto Watanabe1, Masahiko Ohata, Sumio Hayakawa, Mamoru Isemura, Shigenori Kumazawa, Tsutomu Nakayama, Michiyo Furugori, Naohide Kinae.
Abstract
The ethanol extract from Japanese horseradish wasabi was found to inhibit cell proliferation in human monoblastic leukemia U937 cells by inducing apoptotic cell death. Separation by methods including silica gel chromatography and preparative HPLC gave an active compound, which was identified as 6-methylsulfinylhexyl isothiocyanate (6-HITC). Several lines of evidence indicated that 6-HITC induced apoptosis in U937 cells and human stomach cancer MKN45 cells. Thus, 6-HITC is potentially useful as a natural anti-cancer agent.Entities:
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Year: 2003 PMID： 12620325 DOI： 10.1016/s0031-9422(02)00613-1
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072