| Literature DB >> 12620289 |
Takuya Fukushima1, Yasushi Miyazaki, Hideki Tsushima, Chizuko Tsutsumi, Jun Taguchi, Shinichiro Yoshida, Kazutaka Kuriyama, David Scadden, Stephen Nimer, Masao Tomonaga.
Abstract
ETS proteins (such as PU.1, Fli-1 and ETS-1) have been shown to play important roles in normal and abnormal hematopoiesis. We examined the expression of the ELF subfamily of ETS genes (ELF-1, MEF and NERF) in acute myeloid leukemia (AML) cells using Northern blot analysis. ELF-1 and MEF were expressed in all samples, whereas NERF was not. The relative expression (RE) of MEF, but not ELF-1, was significantly lower (P<0.0001) in AML with t(8;21) and t(15;17) compared with AML with normal karyotype. The pattern of MEF expression was not uniform among cells with CD34(+)/CD33(+). It is suggested that the low RE of MEF might be part of a gene expression profile characterizing AML with a good prognosis.Entities:
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Year: 2003 PMID： 12620289 DOI： 10.1016/s0145-2126(02)00214-x
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156