Literature DB >> 19380490

ELF4/MEF activates MDM2 expression and blocks oncogene-induced p16 activation to promote transformation.

Goro Sashida1, Yan Liu, Shannon Elf, Yasuhiko Miyata, Kazuma Ohyashiki, Miki Izumi, Silvia Menendez, Stephen D Nimer.   

Abstract

Several ETS transcription factors, including ELF4/MEF, can function as oncogenes in murine cancer models and are overexpressed in human cancer. We found that Elf4/Mef activates Mdm2 expression; thus, lack of or knockdown of Elf4/Mef reduces Mdm2 levels in mouse embryonic fibroblasts (mef's), leading to enhanced p53 protein accumulation and p53-dependent senescence. Even though p53 is absent in Elf4(-/-) p53(-/-) mef's, neither oncogenic H-Ras(V12) nor c-myc can induce transformation of these cells. This appears to relate to the INK4a/ARF locus; both p19(ARF) and p16 are increased in Elf4(-/-) p53(-/-) mef's, and expression of Bmi-1 or knockdown of p16 in this context restores H-Ras(V12)-induced transformation. Thus, ELF4/MEF promotes tumorigenesis by inhibiting both the p53 and p16/Rb pathways.

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Year:  2009        PMID： 19380490      PMCID： PMC2698769          DOI： 10.1128/MCB.01551-08

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  43 in total

1.  Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53.

Authors:  R Honda; H Tanaka; H Yasuda
Journal:  FEBS Lett       Date:  1997-12-22       Impact factor: 4.124

2.  p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.

Authors:  C A Midgley; D P Lane
Journal:  Oncogene       Date:  1997-09-04       Impact factor: 9.867

3.  Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias.

Authors:  S Mao; R C Frank; J Zhang; Y Miyazaki; S D Nimer
Journal:  Mol Cell Biol       Date:  1999-05       Impact factor: 4.272

4.  MEF, a novel transcription factor with an Elf-1 like DNA binding domain but distinct transcriptional activating properties.

Authors:  Y Miyazaki; X Sun; H Uchida; J Zhang; S Nimer
Journal:  Oncogene       Date:  1996-10-17       Impact factor: 9.867

5.  A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Authors:  G P Dimri; X Lee; G Basile; M Acosta; G Scott; C Roskelley; E E Medrano; M Linskens; I Rubelj; O Pereira-Smith
Journal:  Proc Natl Acad Sci U S A       Date:  1995-09-26       Impact factor: 11.205

6.  Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.

Authors:  M Serrano; A W Lin; M E McCurrach; D Beach; S W Lowe
Journal:  Cell       Date:  1997-03-07       Impact factor: 41.582

Review 7.  Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors.

Authors:  Judith Campisi
Journal:  Cell       Date:  2005-02-25       Impact factor: 41.582

8.  Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF.

Authors:  T Kamijo; F Zindy; M F Roussel; D E Quelle; J R Downing; R A Ashmun; G Grosveld; C J Sherr
Journal:  Cell       Date:  1997-11-28       Impact factor: 41.582

9.  Oncogene-induced senescence as an initial barrier in lymphoma development.

Authors:  Melanie Braig; Soyoung Lee; Christoph Loddenkemper; Cornelia Rudolph; Antoine H F M Peters; Brigitte Schlegelberger; Harald Stein; Bernd Dörken; Thomas Jenuwein; Clemens A Schmitt
Journal:  Nature       Date:  2005-08-04       Impact factor: 49.962

10.  p53 regulates hematopoietic stem cell quiescence.

Authors:  Yan Liu; Shannon E Elf; Yasuhiko Miyata; Goro Sashida; Yuhui Liu; Gang Huang; Silvana Di Giandomenico; Jennifer M Lee; Anthony Deblasio; Silvia Menendez; Jack Antipin; Boris Reva; Andrew Koff; Stephen D Nimer
Journal:  Cell Stem Cell       Date:  2009-01-09       Impact factor: 24.633
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  24 in total

1.  Finding a fairy in the forest: ELF4, a novel and critical element of type I interferon responses.

Authors:  Attila Szabo; Eva Rajnavolgyi
Journal:  Cell Mol Immunol       Date:  2014-03-24       Impact factor: 11.530

2.  The mef/elf4 transcription factor fine tunes the DNA damage response.

Authors:  Goro Sashida; Narae Bae; Silvana Di Giandomenico; Takashi Asai; Nadia Gurvich; Elena Bazzoli; Yan Liu; Gang Huang; Xinyang Zhao; Silvia Menendez; Stephen D Nimer
Journal:  Cancer Res       Date:  2011-05-26       Impact factor: 12.701

Review 3.  The oncogenic role of the ETS transcription factors MEF and ERG.

Authors:  Goro Sashida; Elena Bazzoli; Silvia Menendez; Yan Liu; Stephen D Nimer
Journal:  Cell Cycle       Date:  2010-09-13       Impact factor: 4.534

Review 4.  The p53 tumor suppressor protein regulates hematopoietic stem cell fate.

Authors:  Takashi Asai; Yan Liu; Narae Bae; Stephen D Nimer
Journal:  J Cell Physiol       Date:  2011-09       Impact factor: 6.384

Review 5.  Mdm2 links genotoxic stress and metabolism to p53.

Authors:  Zhongfeng Wang; Baojie Li
Journal:  Protein Cell       Date:  2011-01-08       Impact factor: 14.870

6.  The Many Faces of MDM2 Binding Partners.

Authors:  Maurisa F Riley; Guillermina Lozano
Journal:  Genes Cancer       Date:  2012-03

7.  MEF promotes stemness in the pathogenesis of gliomas.

Authors:  Elena Bazzoli; Teodoro Pulvirenti; Moritz C Oberstadt; Fabiana Perna; Boyoung Wee; Nikolaus Schultz; Jason T Huse; Elena I Fomchenko; Francesca Voza; Viviane Tabar; Cameron W Brennan; Lisa M DeAngelis; Stephen D Nimer; Eric C Holland; Massimo Squatrito
Journal:  Cell Stem Cell       Date:  2012-12-07       Impact factor: 24.633

8.  The transcription factor MEF/Elf4 is dually modulated by p53-MDM2 axis and MEF-MDM2 autoregulatory mechanism.

Authors:  Mary Ann Suico; Ryosuke Fukuda; Rui Miyakita; Kosuke Koyama; Manabu Taura; Tsuyoshi Shuto; Hirofumi Kai
Journal:  J Biol Chem       Date:  2014-07-31       Impact factor: 5.157

Review 9.  The p53 tumor suppressor protein is a critical regulator of hematopoietic stem cell behavior.

Authors:  Yan Liu; Shannon E Elf; Takashi Asai; Yasuhiko Miyata; Yuhui Liu; Goro Sashida; Gang Huang; Silvana Di Giandomenico; Andrew Koff; Stephen D Nimer
Journal:  Cell Cycle       Date:  2009-10-01       Impact factor: 4.534

10.  Mutations in the nucleolar phosphoprotein, nucleophosmin, promote the expression of the oncogenic transcription factor MEF/ELF4 in leukemia cells and potentiates transformation.

Authors:  Koji Ando; Hideki Tsushima; Emi Matsuo; Kensuke Horio; Shinya Tominaga-Sato; Daisuke Imanishi; Yoshitaka Imaizumi; Masako Iwanaga; Hidehiro Itonaga; Shinichiro Yoshida; Tomoko Hata; Ryozo Moriuchi; Hitoshi Kiyoi; Stephen Nimer; Hiroyuki Mano; Tomoki Naoe; Masao Tomonaga; Yasushi Miyazaki
Journal:  J Biol Chem       Date:  2013-02-07       Impact factor: 5.157
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