| Literature DB >> 12620214 |
Abstract
In this issue of Molecular Cell, Ye et al. provide a biological rationale for rapid histone deposition behind the replication fork. They show that defects in nucleosome assembly lead to DNA double-strand breaks and S phase arrest. Their results have important implications for the maintenance of genome integrity in proliferating cells.Mesh:
Substances:
Year: 2003 PMID: 12620214 DOI: 10.1016/s1097-2765(03)00052-2
Source DB: PubMed Journal: Mol Cell ISSN: 1097-2765 Impact factor: 17.970