| Literature DB >> 12617907 |
Todd M Augustus1, Joel Anderson, Suzanne M Hess, Ulrich Bierbach.
Abstract
The preparation of two novel bis(acridine)platinum(II) complexes is reported. The 4+ charged conjugates associate strongly with double-stranded native DNA (K(i)>10(6)), possibly through bisintercalation. A cell viability assay was used to demonstrate that both compounds are capable of mediating cytotoxicity at micromolar concentrations in SNB19 brain tumor cells.Entities:
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Year: 2003 PMID： 12617907 DOI： 10.1016/s0960-894x(02)01078-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823