| Literature DB >> 12613544 |
Abstract
Neuropilins bind the secreted class 3 semaphorins with high affinity but require a member of the plexin family to form receptors that are able to activate downstream signal transduction cascades. In this receptor complex neuropilins act as the ligand-binding subunit while plexins function as the signal-transducing subunit in the induction of cytoskeletal collapse by semaphorins. The cytoplasmic domain is highly conserved within the plexin family and interacts with Rho-like GTPases.Mesh：
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Year: 2002 PMID： 12613544 DOI： 10.1007/978-1-4615-0119-0_6
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622