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Literature DB >> 24589620

Semaphorin 3A: A new player in bone remodeling.

Abstract

Semaphorin 3A (Sema3A) is a protein identified originally as a diffusible axonal chemorepellent. Sema3A has multifunctional roles in embryonic development, immune regulation, vascularization, and oncogenesis. Bone remodeling consists of two phases: the removal of mineralized bone by osteoclasts and the formation of new bone by osteoblasts, and plays an essential role in skeletal diseases such as osteoporosis. Recent studies have shown that Sema3A is implicated in the regulation of osteoblastgenesis and osteoclastgenesis. Moreover, low bone mass in mice with specific knockout of Sema3A in the neurons indicates that Sema3A regulates bone remodeling indirectly. This review highlights recent advances on our understanding of the role of sema3A as a new player in the regulation of bone remodeling and proposes the potential of sema3A in the diagnosis and therapy of bone diseases.

Entities: Disease Gene Species

Keywords: Semaphorin 3A; bone remodeling; osteoblast; osteoclast; sensory innervation

Mesh：

Substances：

Year: 2013 PMID： 24589620 PMCID： PMC3974794 DOI： 10.4161/cam.27752

Source DB: PubMed Journal: Cell Adh Migr ISSN： 1933-6918 Impact factor: 3.405

59 in total

1. Unified nomenclature for the semaphorins/collapsins. Semaphorin Nomenclature Committee.

Authors:
Journal: Cell Date: 1999-05-28 Impact factor: 41.582

2. Expression of Semaphorin-3A and its receptors in endochondral ossification: potential role in skeletal development and innervation.

Authors: C Gomez; B Burt-Pichat; F Mallein-Gerin; B Merle; P D Delmas; T M Skerry; L Vico; L Malaval; C Chenu
Journal: Dev Dyn Date: 2005-10 Impact factor: 3.780

3. Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance.

Authors: Fumikazu Suto; Keisuke Ito; Masato Uemura; Masayuki Shimizu; Yutaka Shinkawa; Makoto Sanbo; Tomoyasu Shinoda; Miu Tsuboi; Seiji Takashima; Takeshi Yagi; Hajime Fujisawa
Journal: J Neurosci Date: 2005-04-06 Impact factor: 6.167

4. Severely suppressed bone turnover: a potential complication of alendronate therapy.

Authors: Clarita V Odvina; Joseph E Zerwekh; D Sudhaker Rao; Naim Maalouf; Frank A Gottschalk; Charles Y C Pak
Journal: J Clin Endocrinol Metab Date: 2004-12-14 Impact factor: 5.958

5. Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury.

Authors: Seiji Okada; Masaya Nakamura; Hiroyuki Katoh; Tamaki Miyao; Takuya Shimazaki; Ken Ishii; Junichi Yamane; Akihiko Yoshimura; Yukihide Iwamoto; Yoshiaki Toyama; Hideyuki Okano
Journal: Nat Med Date: 2006-06-18 Impact factor: 53.440

6. Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis.

Authors: Noriko Takegahara; Hyota Takamatsu; Toshihiko Toyofuku; Tohru Tsujimura; Tatsusada Okuno; Kazunori Yukawa; Masayuki Mizui; Midori Yamamoto; Durbaka V R Prasad; Kazuhiro Suzuki; Masaru Ishii; Kenta Terai; Masayuki Moriya; Yuji Nakatsuji; Saburo Sakoda; Shintaro Sato; Shizuo Akira; Kiyoshi Takeda; Masanori Inui; Toshiyuki Takai; Masahito Ikawa; Masaru Okabe; Atsushi Kumanogoh; Hitoshi Kikutani
Journal: Nat Cell Biol Date: 2006-05-21 Impact factor: 28.824

7. Expression and function of semaphorin 7A in bone cells.

Authors: Guillaume Delorme; Frederic Saltel; Edith Bonnelye; Pierre Jurdic; Irma Machuca-Gayet
Journal: Biol Cell Date: 2005-07 Impact factor: 4.458

8. Capsaicin-sensitive sensory neurons contribute to the maintenance of trabecular bone integrity.

Authors: Sarah C Offley; Tian-Zhi Guo; Tzuping Wei; J David Clark; Hannes Vogel; Derek P Lindsey; Christopher R Jacobs; Wei Yao; Nancy E Lane; Wade S Kingery
Journal: J Bone Miner Res Date: 2004-11-16 Impact factor: 6.741

9. Collapsin: a protein in brain that induces the collapse and paralysis of neuronal growth cones.

Authors: Y Luo; D Raible; J A Raper
Journal: Cell Date: 1993-10-22 Impact factor: 41.582

10. Semaphorin III is needed for normal patterning and growth of nerves, bones and heart.

Authors: O Behar; J A Golden; H Mashimo; F J Schoen; M C Fishman
Journal: Nature Date: 1996-10-10 Impact factor: 49.962

19 in total

1. Influence of Mechanical Force on Bone Matrix Proteins in Ovariectomised Mice and Osteoblast-like MC3T3-E1 Cells.

Authors: Meng Zhang; Shintaro Ishikawa; Tomoko Inagawa; Hideshi Ikemoto; Shiyu Guo; Masataka Sunagawa; Tadashi Hisamitsu
Journal: In Vivo Date: 2017-01-02 Impact factor: 2.155

2. Regulation of mesenchymal stem cell differentiation on microstructured titanium surfaces by semaphorin 3A.

Authors: Ethan M Lotz; Michael B Berger; Barbara D Boyan; Zvi Schwartz
Journal: Bone Date: 2020-02-03 Impact factor: 4.398

3. Opening windows for bone remodeling through a SLIT.

Authors: Jameel Iqbal; Tony Yuen; Se-Min Kim; Mone Zaidi
Journal: J Clin Invest Date: 2018-03-05 Impact factor: 14.808

4. Adenosine A_2A receptor (A2AR) stimulation modulates expression of semaphorins 4D and 3A, regulators of bone homeostasis.

Authors: Aránzazu Mediero; Tuere Wilder; Lopa Shah; Bruce N Cronstein
Journal: FASEB J Date: 2018-02-02 Impact factor: 5.191

5. Cationic Peptides and Peptidomimetics Bind Glycosaminoglycans as Potential Sema3A Pathway Inhibitors.

Authors: Miriam Corredor; Roman Bonet; Alejandra Moure; Cecilia Domingo; Jordi Bujons; Ignacio Alfonso; Yolanda Pérez; Àngel Messeguer
Journal: Biophys J Date: 2016-03-29 Impact factor: 4.033

6. Naringin ameliorates bone loss induced by sciatic neurectomy and increases Semaphorin 3A expression in denervated bone.

Authors: Xinlong Ma; Jianwei Lv; Xiaolei Sun; Jianxiong Ma; Guosheng Xing; Ying Wang; Lei Sun; Jianbao Wang; Fengbo Li; Yanjun Li; Zhihu Zhao
Journal: Sci Rep Date: 2016-04-25 Impact factor: 4.379

7. Semaphorin 3A promotes activation of Pax7, Myf5, and MyoD through inhibition of emerin expression in activated satellite cells.

Authors: Mulan Qahar; Yuko Takuma; Wataru Mizunoya; Ryuichi Tatsumi; Yoshihide Ikeuchi; Mako Nakamura
Journal: FEBS Open Bio Date: 2016-04-27 Impact factor: 2.693

8. Semaphorin 3A Shifts Adipose Mesenchymal Stem Cells towards Osteogenic Phenotype and Promotes Bone Regeneration In Vivo.

Authors: Xiangwei Liu; Naiwen Tan; Yuchao Zhou; Xueying Zhou; Hui Chen; Hongbo Wei; Ji Chen; Xiaoru Xu; Sijia Zhang; Guodong Yang; Yingliang Song
Journal: Stem Cells Int Date: 2016-09-19 Impact factor: 5.443

9. Adenovirus-mediated delivery of Sema3A alleviates rheumatoid arthritis in a serum-transfer induced mouse model.

Authors: Yue Teng; Zhanhai Yin; Jing Li; Kun Li; Xu Li; Yan Zhang
Journal: Oncotarget Date: 2017-08-03

10. Identification of novel genes in aging osteoblasts using next-generation sequencing and bioinformatics.

Authors: Yi-Jen Chen; Wei-An Chang; Ming-Shyan Huang; Chia-Hsin Chen; Kuan-Yuan Wang; Ya-Ling Hsu; Po-Lin Kuo
Journal: Oncotarget Date: 2017-11-28