Literature DB >> 12612643

Towards an e-biology of ageing: integrating theory and data.

Thomas B L Kirkwood1, Richard J Boys, Colin S Gillespie, Carole J Proctor, Daryl P Shanley, Darren J Wilkinson.   

Abstract

Ageing is a highly complex process; it involves interactions between numerous biochemical and cellular mechanisms that affect many tissues in an organism. Although work on the biology of ageing is now advancing quickly, this inherent complexity means that information remains highly fragmented. We describe how a new web-based modelling initiative is seeking to integrate data and hypotheses from diverse biological sources.

Entities:  

Mesh:

Year:  2003        PMID: 12612643     DOI: 10.1038/nrm1051

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN: 1471-0072            Impact factor:   94.444


  21 in total

Review 1.  Systems biology of ageing and longevity.

Authors:  Thomas B L Kirkwood
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2011-01-12       Impact factor: 6.237

2.  Time of our lives. What controls the length of life?

Authors:  Thomas B L Kirkwood
Journal:  EMBO Rep       Date:  2005-07       Impact factor: 8.807

Review 3.  Toward a systems biology framework for understanding aging and health span.

Authors:  Geoffrey B West; Aviv Bergman
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2009-02-17       Impact factor: 6.053

Review 4.  Stochastic modelling for quantitative description of heterogeneous biological systems.

Authors:  Darren J Wilkinson
Journal:  Nat Rev Genet       Date:  2009-02       Impact factor: 53.242

5.  Lithocholic acid extends longevity of chronologically aging yeast only if added at certain critical periods of their lifespan.

Authors:  Michelle T Burstein; Pavlo Kyryakov; Adam Beach; Vincent R Richard; Olivia Koupaki; Alejandra Gomez-Perez; Anna Leonov; Sean Levy; Forough Noohi; Vladimir I Titorenko
Journal:  Cell Cycle       Date:  2012-08-16       Impact factor: 4.534

6.  Web-based applications for building, managing and analysing kinetic models of biological systems.

Authors:  Dong-Yup Lee; Rajib Saha; Faraaz Noor Khan Yusufi; Wonjun Park; Iftekhar A Karimi
Journal:  Brief Bioinform       Date:  2008-09-19       Impact factor: 11.622

7.  GSK3 and p53 - is there a link in Alzheimer's disease?

Authors:  Carole J Proctor; Douglas A Gray
Journal:  Mol Neurodegener       Date:  2010-01-26       Impact factor: 14.195

8.  Modelling the response of FOXO transcription factors to multiple post-translational modifications made by ageing-related signalling pathways.

Authors:  Graham R Smith; Daryl P Shanley
Journal:  PLoS One       Date:  2010-06-14       Impact factor: 3.240

9.  Rule-based cell systems model of aging using feedback loop motifs mediated by stress responses.

Authors:  Andres Kriete; William J Bosl; Glenn Booker
Journal:  PLoS Comput Biol       Date:  2010-06-17       Impact factor: 4.475

10.  Feedback between p21 and reactive oxygen production is necessary for cell senescence.

Authors:  João F Passos; Glyn Nelson; Chunfang Wang; Torsten Richter; Cedric Simillion; Carole J Proctor; Satomi Miwa; Sharon Olijslagers; Jennifer Hallinan; Anil Wipat; Gabriele Saretzki; Karl Lenhard Rudolph; Tom B L Kirkwood; Thomas von Zglinicki
Journal:  Mol Syst Biol       Date:  2010-02-16       Impact factor: 11.429

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.