1,4-Dichlorobenzene-Induced liver tumors in the mouse: evaluation of the role of chlorohydroquinones.

1,4-Dichlorobenzene (1,4-DCB) is a wide-spread environmental contaminant and well-described hepatotoxicant for rats and mice. The prolonged oral or inhalation exposure to 1,4-DCB is associated with an increased frequency of hepatic tumors in mice, but not in rats. Evidence is lacking of direct genotoxicity with 1,4-DCB or its metabolites, and no generally accepted mechanism has been found to account for the increased numbers of 1,4-DCB-induced hepatic tumors in mice. No information is available on the carcinogenic effects of 1,4-DCB in humans. Here we consider evidence that the biotransformation of 1,4-DCB to substituted hydroquinone species contributes to hepatic adenoma and carcinoma formation in mouse liver. This phenomenon has implications for human carcinogenesis.