Literature DB >> 12609665

HPLC method for the analysis of harmol, harmalol, harmine and harmaline in the seeds of Peganum harmala L.

M Kartal1, M L Altun, S Kurucu.   

Abstract

A simple and sensitive method for separation and determination of harmol, harmalol, harmine and harmaline has been developed and validated. Harmol, harmalol, harmine and harmaline were separated using a Metasil ODS column by isocratic elution with flow rate 1.5 ml/min. The mobile phase composition was Isopropyl alcohol-Acetonitrile-Water-Formic acid (100:100:300:0.3) (v/v/v/v) and pH adjusted 8.6 with triethylamine. Spectrophotometric detection was carried out at 330 nm. The linear range of detection for harmol, harmalol, harmine and harmaline were between 9.375-250, 30.750-246, 31.250-500 and 31.000-248 microg/ml, respectively. The method described was suitable for the determination of harmol, harmalol, harmine and harmaline in the seeds of Peganum harmala L.

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Year:  2003        PMID： 12609665     DOI： 10.1016/s0731-7085(02)00568-x

Source DB:  PubMed          Journal:  J Pharm Biomed Anal        ISSN： 0731-7085            Impact factor:   3.935


  13 in total

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10.  A Series of β-Carboline Alkaloids from the Seeds of Peganum harmala Show G-Quadruplex Interactions.

Authors:  Kai-Bo Wang; Da-Hong Li; Ping Hu; Wen-Jing Wang; Clement Lin; Jian Wang; Bin Lin; Jiao Bai; Yue-Hu Pei; Yong-Kui Jing; Zhan-Lin Li; Danzhou Yang; Hui-Ming Hua
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