| Literature DB >> 12608860 |
Suresh Awale1, Yasuhiro Tezuka, Arjun H Banskota, I Ketut Adnyana, Shigetoshi Kadota.
Abstract
A methanolic extract of Orthosiphon stamineus yielded six new highly oxygenated isopimarane-type diterpenes, orthosiphols U-Z (1-6), and 15 previously reported diterpenes. The isolated diterpenes all showed significant dose-dependent inhibitory effects on the nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells. Orthosiphols A (7), B (8), D (9), and X (4) showed more potent inhibitory activities than a positive control, N(G)-monomethyl-l-arginine (l-NMMA), and 1 displayed the strongest activity with an IC(50) value of 6.4 microM.Entities:
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Year: 2003 PMID： 12608860 DOI： 10.1021/np020455x
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050